INT198749

Context Info Confidence 0.53 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 2.14 Pain Relevance 0.54

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4) cytoplasm (Dlg4)

Anatomy Link Frequency synapses 3 neurons 2 hypothalamus 1 cortex 1 Dlg4 (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 6 98.12 Dopamine 33 97.84 nMDA receptor 21 93.08 imagery 63 87.32 depression 9 77.08 cytokine 9 72.48 Glutamate receptor 5 69.12 Pyramidal cell 16 55.04 Thalamus 9 43.24 monoamine 39 40.32

Disease Link Frequency Relevance Heat Targeted Disruption 332 98.56 Schizophrenia 39 97.20 Congenital Anomalies 34 95.12 Retts Disease 34 82.80 Depression 9 77.08 Manic Depressive Disorder 6 76.44 Hepatitis 3 59.36 Cognitive Disorder 45 53.08 Stress 3 50.12 Anxiety Disorder 11 46.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Synaptophysin and PSD95 were downregulated in the hypothalamus and syntaxin 1a and synaptotagmin were significantly decreased in the cortex of Mecp2?

Negative_regulation (downregulated) of PSD95 in hypothalamus

1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.27 Pain Relevance 0

The rapid redistribution of PSD-95, and other PSD molecules, could cause rapid shifts in synapse size and strength towards the more active inputs.

Negative_regulation (redistribution) of PSD-95 in synapse

2) Confidence 0.42 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0.06 Pain Relevance 0

These measurements show that the retention time for PSD-95 and the size of the PSD-95 cluster are tightly coupled at the level of single synapses.

Negative_regulation (coupled) of PSD-95 cluster in synapses

3) Confidence 0.42 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04

These measurements show that the retention time for PSD-95 and the size of the PSD-95 cluster are tightly coupled at the level of single synapses.

Negative_regulation (coupled) of PSD-95 in synapses

4) Confidence 0.36 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04

Both NR1 and PSD-95 were markedly reduced in the prefrontal cortex of HB-EGF KO mice (P<0.01 vs. control mice) (Fig. 4d, i, and j).

Negative_regulation (reduced) of PSD-95 in cortex associated with targeted disruption

5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.82 Pain Relevance 0.07

These knockout mice showed (a) behavioral abnormalities similar to those described in psychiatric disorders, which were ameliorated by typical or atypical antipsychotics, (b) altered dopamine and serotonin levels in the brain, (c) decreases in spine density in neurons of the prefrontal cortex, (d) reductions in the protein levels of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor and post-synaptic protein-95 (PSD-95), (e) decreases in the EGF receptor, and in the calcium/calmodulin-dependent protein kinase II (CaMK II) signal cascade.

Negative_regulation (reductions) of PSD-95 in neurons associated with targeted disruption, dopamine, congenital anomalies and serotonin

6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.49 Pain Relevance 0.17

20HA co-immunoprecipitated with both NR1 and NR2B, even in the absence of PSD-95 (Figure 4A, lane 2 and 3, respectively).

Negative_regulation (absence) of PSD-95

7) Confidence 0.21 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03

These knockout mice showed (a) behavioral abnormalities similar to those described in psychiatric disorders, which were ameliorated by typical or atypical antipsychotics, (b) altered dopamine and serotonin levels in the brain, (c) decreases in spine density in neurons of the prefrontal cortex, (d) reductions in the protein levels of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor and post-synaptic protein-95 (PSD-95), (e) decreases in the EGF receptor, and in the calcium/calmodulin-dependent protein kinase II (CaMK II) signal cascade.

Negative_regulation (reductions) of protein-95 in neurons associated with targeted disruption, dopamine, congenital anomalies and serotonin

8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.49 Pain Relevance 0.17

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