INT198750

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.60
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
spines 4
dentate gyrus 2
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 44 98.64 Very High Very High Very High
Somatosensory cortex 7 96.56 Very High Very High Very High
nMDA receptor 58 96.16 Very High Very High Very High
Dynorphin 2 91.12 High High
Pyramidal cell 6 89.32 High High
opiate 1 87.88 High High
Spinal sensitization 1 87.60 High High
central sensitization 9 80.52 Quite High
Lasting pain 8 61.60 Quite High
Eae 1 50.48 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 2 100.00 Very High Very High Very High
Cognitive Disorder 21 95.60 Very High Very High Very High
Targeted Disruption 27 76.92 Quite High
Pain 11 61.60 Quite High
Depression 34 50.00 Quite Low
Anxiety Disorder 33 50.00 Quite Low
Nociception 29 25.44 Quite Low
Hyperalgesia 5 20.80 Low Low
INFLAMMATION 9 20.28 Low Low
Adhesions 2 14.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that the overexpression of PSD-95 can enhance synaptic strength [38,39] and spine size [48].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PSD-95 in spine
1) Confidence 0.68 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.19
What governs the diffusional exchange of PSD-95 between spines?
Positive_regulation (governs) of Gene_expression (exchange) of PSD-95 in spines
2) Confidence 0.43 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
We found that the expression of PSD-95 is not changed in TgDREAM mice, however, co-immunoprecipitation experiments show that there is a direct interaction between DREAM and PSD-95.
Neg (not) Positive_regulation (changed) of Gene_expression (expression) of PSD-95
3) Confidence 0.35 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.06 Pain Relevance 0.64
For example, object exploration also increases Arc, CaMKII and PSD95 expression in the dentate gyrus (Soulé et al., 2008) and both Arc and CaMKII inactivation in mutant mice have deficient object recognition memory (Miller et al., 2002; Plath et al., 2006).
Positive_regulation (increases) of Gene_expression (expression) of PSD95 in dentate gyrus associated with cognitive disorder and aids-related complex
4) Confidence 0.18 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.54 Pain Relevance 0.03
But, the over-expression of PSD-95 may enhance AMPA receptor-mediated synaptic responses.
Positive_regulation (enhance) of Gene_expression (expression) of PSD-95
5) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.12

General Comments

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