INT198751

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Psd) intracellular (Psd) cytoplasm (Psd)
Anatomy Link Frequency
synapse 1
hippocampus 1
Psd (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 99.48 Very High Very High Very High
Glutamate receptor 9 98.44 Very High Very High Very High
long-term potentiation 57 79.68 Quite High
nMDA receptor 20 50.32 Quite High
Glutamate 2 39.36 Quite Low
Catecholamine 20 9.08 Low Low
imagery 27 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 87.04 High High
Hepatitis 1 60.56 Quite High
Pheochromocytoma 32 59.40 Quite High
Body Weight 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 4 5.00 Very Low Very Low Very Low
Anaerobic Bacterial Infections 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because no changes were observed in total hippocampus homogenate, the specific decrease in the PSD is therefore attributed to changes in glutamate receptor subunit trafficking or clustering in the PSD instead of a reduced protein translation.
Negative_regulation (decrease) of PSD in hippocampus associated with glutamate receptor and hippocampus
1) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.21 Pain Relevance 0.33
The rapid redistribution of PSD-95, and other PSD molecules, could cause rapid shifts in synapse size and strength towards the more active inputs.


Negative_regulation (redistribution) of PSD in synapse
2) Confidence 0.22 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0.06 Pain Relevance 0
We observed a specific reduction of key proteins in the PSD (i.e., GluR1, NR2B, and p286-?
Negative_regulation (reduction) of PSD
3) Confidence 0.18 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.20 Pain Relevance 0.33

General Comments

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