INT198753

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 1.66
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Psd) intracellular (Psd) cytoplasm (Psd)
Anatomy Link Frequency
spine 3
synapse 2
synaptic vesicles 1
Psd (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 36 99.98 Very High Very High Very High
Glutamate receptor 153 99.56 Very High Very High Very High
depression 194 97.20 Very High Very High Very High
long-term potentiation 104 95.08 Very High Very High Very High
Hippocampus 41 94.08 High High
Pyramidal cell 26 87.20 High High
GABAergic 58 81.04 Quite High
imagery 206 76.08 Quite High
Somatosensory cortex 27 72.96 Quite High
medulla 4 72.80 Quite High
Disease Link Frequency Relevance Heat
Depression 194 97.20 Very High Very High Very High
Wallerian Degeneration 15 94.80 High High
Syndrome 15 86.36 High High
Respiratory Failure 2 68.20 Quite High
Targeted Disruption 27 62.76 Quite High
Adhesions 11 58.44 Quite High
Injury 7 51.44 Quite High
Congenital Anomalies 15 50.40 Quite High
Autism 3 50.00 Quite Low
Generalized Anxiety Disorder 4 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presynaptic terminal has electron dense cytoplasm with the apparent loss of integrity of synaptic vesicles and other organelles, but the presynaptic membrane remains intact and closely adhering to the PSD membrane (Lund and Lund, 1971; Nadler et al., 1980).
PSD Binding (adhering) of in synaptic vesicles
1) Confidence 0.20 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.31 Pain Relevance 0.03
r is set primarily by the interactions of PSD-95 with its binding partners in the PSD and only modulated by compartmentalization of diffusing PSD-95-paGFP* by spine necks (see Equation 1 in Discussion).


PSD Binding (partners) of in spine
2) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
r is set primarily by the interactions of PSD-95 with its binding partners in the PSD and only modulated by compartmentalization of diffusing PSD-95-paGFP* by spine necks (see Equation 1 in Discussion).


PSD Binding (binding) of in spine
3) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Therefore, the kinetic interactions between PSD-95 and the PSD may help to determine PSD size.


PSD Binding (interactions) of
4) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.15
PSD size should also play a role, since the number of binding sites for PSD-95 in the PSD is likely proportional to PSD size, larger PSDs could capture more PSD-95.
PSD Binding (binding) of
5) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
Interactions between PSD-95 molecules in the PSD are also likely required to maintain stable PSD-95 clusters [72].
PSD Binding (Interactions) of
6) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Despite its important structural role, biochemical measurements in dissociated cultures have suggested that PSD-95 and other associated PSD proteins have short half-lives [23,40–42].
PSD Binding (associated) of
7) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0.06 Pain Relevance 0
GKAP is a PSD-95-binding protein that forms an important component of the postsynaptic density (PSD), where protein-protein interactions between scaffolding proteins and receptors are a key mechanism in assembling a functional synapse [2].
PSD Binding (interactions) of in synapse
8) Confidence 0.18 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.09 Pain Relevance 0.03
Delphilin, PSD-95 and SAP102 share similarities at the molecular levels–they are PSD proteins interacting with the carboxyl-terminal of glutamate receptors.
PSD Binding (interacting) of associated with glutamate receptor
9) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.45 Pain Relevance 0.61
Delphilin, PSD-95 and SAP102 share similarities at the molecular levels–they are PSD proteins interacting with the carboxyl-terminal of glutamate receptors.
PSD Binding (interacting) of associated with glutamate receptor
10) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.39 Pain Relevance 0.59
Significant changes in protein levels of NMDA receptor subunits NR1 and NR2A, and NMDA receptor interacting proteins PSD-95 and SAP97 were not detected.
PSD Binding (interacting) of associated with nmda receptor
11) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0.38
Although the interactions of PSD-95 with its binding partners in the PSD set the magnitude of ?
PSD Binding (partners) of
12) Confidence 0.17 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
Although the interactions of PSD-95 with its binding partners in the PSD set the magnitude of ?
PSD Binding (binding) of
13) Confidence 0.17 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
Developmentally regulated protein–protein interactions in the PSD therefore could underlie the developmental increase in retention times (through changes in ?
PSD Binding (interactions) of
14) Confidence 0.17 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
Truncation of the carboxyl-terminal PSD-95/Discs large/zona occludens-1 (PDZ)-binding domain of GluR?
PSD Binding (binding) of associated with glutamate receptor
15) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.23 Pain Relevance 0.74
After blocking nonspecific protein interactions with 10% albumin in Tris-buffered saline (TBS), the nitrocellulose papers were incubated for 2 hr at room temperature with the primary antibodies: NR1 (1:1000; Pharmingen, San Diego, CA, USA), NR2A (1:1000; Zymed, San Francisco, CA, USA), NR2B (1:1000; Zymed), GluR1 (1:1500; Chemicon, Temecula, CA, USA), PSD-95 (1:2000; Affinity BioReagents, Golden, CO, USA), SAP97 (1:1000; StressGen, San Diego, CA, USA), Ca2+/calmodulin-dependent protein kinase II (?
PSD Neg (blocking) Binding (blocking) of
16) Confidence 0.15 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0 Pain Relevance 0.03
The scaffold protein of excitatory synapses, PSD 95, binds to all neuroligins, although neuroligin-2 is preferentially found at inhibitory synapses.
PSD Binding (binds) of in synapses
17) Confidence 0.11 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.13 Pain Relevance 0.17
Dlc1/2 also occur in excitatory synapses of dendritic spines, where they bind to GKAP/PSD-95.
PSD Binding (bind) of in spines
18) Confidence 0.08 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.04

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