INT198754

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 0.09
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spine 2
synapse 2
dendrite 1
Neocortex 1
Psds1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 252 97.60 Very High Very High Very High
Pyramidal cell 12 91.44 High High
long-term potentiation 12 81.56 Quite High
Somatosensory cortex 36 77.20 Quite High
isoflurane 48 5.00 Very Low Very Low Very Low
dexamethasone 12 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Glutamate receptor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 88.56 High High
Hepatitis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Large PSDs are large sources of diffusing PSD-95, and a net diffusional flux is expected to carry PSD-95 from large to small synapses.
Gene_expression (sources) of PSDs in synapses
1) Confidence 0.16 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Without synapse-specific regulation of kinetic parameters, the interactions between PSD molecules and PSDs are identical in all spines; large PSDs would therefore lose material and size at the expense of small PSDs, until all PSDs have a similar size.
Gene_expression (molecules) of PSDs in synapse
2) Confidence 0.16 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Therefore, PSDs captured diffusing PSD-95-paGFP* in proportion to their size.
Gene_expression (captured) of PSDs
3) Confidence 0.16 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Therefore large PSDs contain large PSD-95 clusters and are prominent sources of PSD-95, and the resulting concentration gradients along the dendrite will drive net PSD-95 flux from large PSDs towards small PSDs.
Gene_expression (sources) of PSDs in dendrite
4) Confidence 0.16 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
To estimate the size of the PSD-95 clusters in PSDs containing PSD-95-paGFP, we measured the green fluorescence approximately 1–2 min after saturating photoactivation and background subtraction.
Gene_expression (containing) of PSDs
5) Confidence 0.16 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.11
Stable PSDs in the Developing Neocortex In Vivo
Gene_expression (Stable) of PSDs in Neocortex
6) Confidence 0.14 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.16
Thus individual PSDs compete for a limiting pool of PSD-95; an increase in the size of the PSD-95 cluster in one spine occurs at the expense of neighboring PSDs (Figure S3).
Gene_expression (compete) of PSDs in spine
7) Confidence 0.14 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
Thus individual PSDs compete for a limiting pool of PSD-95; an increase in the size of the PSD-95 cluster in one spine occurs at the expense of neighboring PSDs (Figure S3).
Gene_expression (expense) of PSDs in spine
8) Confidence 0.14 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
To begin to address this question, we studied the dynamics of PSD-95 in single PSDs in vivo [26].
Gene_expression (dynamics) of PSDs
9) Confidence 0.14 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0.09 Pain Relevance 0
Second, larger PSDs retain PSD-95 for longer than smaller PSDs (Figure 5B), which helps maintain differences in the sizes of PSD-95 clusters.
Gene_expression (retain) of PSDs
10) Confidence 0.14 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Second, larger PSDs retain PSD-95 for longer than smaller PSDs (Figure 5B), which helps maintain differences in the sizes of PSD-95 clusters.
Gene_expression (retain) of PSDs
11) Confidence 0.14 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Larger PSDs hold onto PSD-95 for longer and capture PSD-95 more efficiently than smaller PSDs.
Gene_expression (hold) of PSDs
12) Confidence 0.14 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox