INT198755

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.60
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
spine 3
synapse 1
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 9 96.28 Very High Very High Very High
Glutamate 120 87.64 High High
imagery 105 87.44 High High
Glutamate receptor 14 76.28 Quite High
long-term potentiation 9 52.96 Quite High
Neurotransmitter 10 50.00 Quite Low
addiction 6 42.84 Quite Low
Pain 1 41.28 Quite Low
Hippocampus 25 39.44 Quite Low
isoflurane 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 84 99.96 Very High Very High Very High
Aids-related Complex 3 97.92 Very High Very High Very High
Death 10 93.04 High High
Stress 24 92.28 High High
Nervous System Malformation 8 77.68 Quite High
Schizophrenia 13 76.72 Quite High
Adhesions 14 46.32 Quite Low
Drug Dependence 1 42.84 Quite Low
Pain 1 41.28 Quite Low
Disease 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of a TAP-tagged PSD-95 knockin mouse line
Positive_regulation (Generation) of TAP-tagged PSD-95 associated with targeted disruption
1) Confidence 0.59 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.18 Pain Relevance 0.03
We measured PSD-95 clusters (Gmax of photoactivated PSD-95-paGFP) and ?
Positive_regulation (photoactivated) of PSD-95-paGFP
2) Confidence 0.49 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.07
Using two-photon photoactivation of PSD-95 tagged with photoactivatable GFP (paGFP), we measured the time over which PSD-95 molecules were retained in individual spines.
Positive_regulation (photoactivation) of PSD-95 in spines
3) Confidence 0.49 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Therefore, PSDs captured diffusing PSD-95-paGFP* in proportion to their size.
Positive_regulation (diffusing) of PSD-95-paGFP
4) Confidence 0.43 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
After photoactivating PSD-95-paGFP in a single spine, fluorescence appeared in neighboring spines as fluorescence decreased in the photoactivated spine (Figure 4A).
Positive_regulation (photoactivating) of PSD-95-paGFP in spine
5) Confidence 0.43 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Thus individual PSDs compete for a limiting pool of PSD-95; an increase in the size of the PSD-95 cluster in one spine occurs at the expense of neighboring PSDs (Figure S3).
Positive_regulation (increase) of PSD-95 cluster in spine
6) Confidence 0.40 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
The observed increases in gene expression for the synaptic membrane scaffold proteins (Dlg1, Dlg2, and Dlg4), and a protein involved in synapse strengthening (Arc, Activity-Regulated Cytoskeleton-Associated Protein), also fit a pattern of new synapse growth.
Positive_regulation (increases) of Dlg4 in synapse associated with aids-related complex
7) Confidence 0.20 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.42 Pain Relevance 0.28

General Comments

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