INT198776

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.05
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
dendrite 1
synapses 1
Dlg4 (Mus musculus)
Psds1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 7 80.00 Quite High
Pyramidal cell 7 49.76 Quite Low
imagery 147 38.64 Quite Low
Somatosensory cortex 21 35.52 Quite Low
isoflurane 28 5.00 Very Low Very Low Very Low
long-term potentiation 7 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Glutamate receptor 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 7 52.72 Quite High
Hepatitis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
off. (1) Larger PSDs could contain different PSD-95 binding partners and thus interact more strongly with PSD-95 compared to smaller PSDs; (2) Individual PSD-95 molecules simultaneously interact with multiple binding partners.
PSD-95 Binding (interact) of PSDs
1) Confidence 0.11 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Since the ratio of PSD area over PSD circumference increases with PSD size, large PSDs could bind PSD-95 more strongly; (3) PSD-95 association with the PSD is controlled by activity-dependent post-translational modifications, and these could be regulated differently at different synapses [33,41].
PSD-95 Binding (bind) of PSDs in synapses
2) Confidence 0.11 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
PSD-95 was bound to individual PSDs for approximately 30 min before diffusing into the dendrite and to other synapses.
PSD-95 Binding (bound) of PSDs in dendrite
3) Confidence 0.10 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0.05 Pain Relevance 0
off. (1) Larger PSDs could contain different PSD-95 binding partners and thus interact more strongly with PSD-95 compared to smaller PSDs; (2) Individual PSD-95 molecules simultaneously interact with multiple binding partners.
PSD-95 Binding (interact) of PSDs
4) Confidence 0.09 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
off. (1) Larger PSDs could contain different PSD-95 binding partners and thus interact more strongly with PSD-95 compared to smaller PSDs; (2) Individual PSD-95 molecules simultaneously interact with multiple binding partners.
PSD-95 Binding (interact) of PSDs
5) Confidence 0.09 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
off. (1) Larger PSDs could contain different PSD-95 binding partners and thus interact more strongly with PSD-95 compared to smaller PSDs; (2) Individual PSD-95 molecules simultaneously interact with multiple binding partners.
PSD-95 Binding (interact) of PSDs
6) Confidence 0.08 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
off. (1) Larger PSDs could contain different PSD-95 binding partners and thus interact more strongly with PSD-95 compared to smaller PSDs; (2) Individual PSD-95 molecules simultaneously interact with multiple binding partners.
PSD-95 Binding (interact) of PSDs
7) Confidence 0.08 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04

General Comments

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