INT198779

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.09
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4, Psd) cytoplasm (Dlg4, Psd) structural molecule activity (Dlg4)
intracellular (Psd) protein complex assembly (Dlg4)
Anatomy Link Frequency
spine 2
synapse 2
dendrite 1
tail 1
Dlg4 (Mus musculus)
Psd (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 13 87.20 High High
imagery 189 81.36 Quite High
Somatosensory cortex 27 72.96 Quite High
addiction 10 58.56 Quite High
long-term potentiation 35 51.80 Quite High
isoflurane 36 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Glutamate receptor 11 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 9 86.08 High High
Sprains And Strains 1 34.40 Quite Low
Convulsion 2 13.56 Low Low
Hepatitis 9 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Helminth Infection 1 5.00 Very Low Very Low Very Low
Influenza Virus Infection 1 5.00 Very Low Very Low Very Low
Contagious Ecthyma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the ratio of PSD area over PSD circumference increases with PSD size, large PSDs could bind PSD-95 more strongly; (3) PSD-95 association with the PSD is controlled by activity-dependent post-translational modifications, and these could be regulated differently at different synapses [33,41].
PSD-95 Binding (association) of PSD in synapses
1) Confidence 0.25 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Interactions between PSD-95 molecules in the PSD are also likely required to maintain stable PSD-95 clusters [72].
PSD-95 Binding (Interactions) of PSD
2) Confidence 0.21 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
After PSD-95 unbinds from the PSD, it diffuses rapidly (inter-synapse diffusion times ~ 50 ms, Protocol S1) along the dendritic shaft until it is captured by other PSDs.
PSD-95 Binding (unbinds) of PSD in synapse
3) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
After PSD-95 unbinds from a PSD, it diffuses rapidly within the dendrite and binds to other PSDs (Figure 4A).
PSD-95 Binding (unbinds) of PSD in dendrite
4) Confidence 0.19 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
r is set primarily by the interactions of PSD-95 with its binding partners in the PSD and only modulated by compartmentalization of diffusing PSD-95-paGFP* by spine necks (see Equation 1 in Discussion).


PSD-95 Binding (interactions) of PSD in spine
5) Confidence 0.18 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
r is set primarily by the interactions of PSD-95 with its binding partners in the PSD and only modulated by compartmentalization of diffusing PSD-95-paGFP* by spine necks (see Equation 1 in Discussion).


PSD-95 Binding (interactions) of PSD in spine
6) Confidence 0.18 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
Therefore, the kinetic interactions between PSD-95 and the PSD may help to determine PSD size.


PSD-95 Binding (interactions) of PSD
7) Confidence 0.18 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.15
We focused on PSD-95 because it is a major organizer of the PSD.
PSD-95 Binding (organizer) of PSD
8) Confidence 0.17 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0.09 Pain Relevance 0
Although the interactions of PSD-95 with its binding partners in the PSD set the magnitude of ?
PSD-95 Binding (interactions) of PSD
9) Confidence 0.16 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
The yeast two-hybrid system was initially used to determine whether the cytoplasmic tail of Neto1 could interact with PSD-95 and the related proteins PSD-93, SAP-102, and SAP-97.
PSD-95 Binding (interact) of PSD in tail
10) Confidence 0.10 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox