INT1988

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2011
Negated 17
Speculated 9
Reported most in Abstract
Documents 254
Total Number 263
Disease Relevance 59.25
Pain Relevance 68.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
pancreas 28
blood 24
plasma 22
pancreatic islets 22
liver 8
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 153 100.00 Very High Very High Very High
Somatostatin 110 100.00 Very High Very High Very High
Enkephalin 109 100.00 Very High Very High Very High
Bile 64 100.00 Very High Very High Very High
Opioid 38 100.00 Very High Very High Very High
Kinase C 35 100.00 Very High Very High Very High
adenocard 10 100.00 Very High Very High Very High
Morphine 58 99.98 Very High Very High Very High
Glutamate 53 99.98 Very High Very High Very High
Serotonin 5 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 118 100.00 Very High Very High Very High
Hyperinsulinism 85 100.00 Very High Very High Very High
Impaired Glucose Tolerance 198 99.90 Very High Very High Very High
Diabetes Mellitus 1673 99.84 Very High Very High Very High
Bordatella Infection 57 99.84 Very High Very High Very High
Obesity 171 99.64 Very High Very High Very High
Urological Neuroanatomy 10 99.64 Very High Very High Very High
Hyperglycemia 117 99.32 Very High Very High Very High
Body Weight 242 99.18 Very High Very High Very High
Cognitive Disorder 86 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that intestinal osmolality may enhance insulin release to intravenous glucose, but not to arginine in the rat.
Neg (not) Spec (may) Positive_regulation (enhance) of Localization (release) of insulin
1) Confidence 0.69 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2117758 Disease Relevance 0 Pain Relevance 0.07
We conclude that immediately after hepatic dearterialization in rats with liver malignancies, glucose intolerance and impaired glucose-induced insulin secretion exist.
Positive_regulation (induced) of Localization (secretion) of insulin in liver associated with impaired glucose tolerance
2) Confidence 0.69 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2666752 Disease Relevance 0.48 Pain Relevance 0.06
These peptides (3.95 X 10(-8) M), like morphine (3.95 X 10(-8) M), significantly inhibited the glucose-induced insulin secretion.
Positive_regulation (induced) of Localization (secretion) of insulin associated with morphine
3) Confidence 0.69 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.47
Morphine sulphate (5 X 10(-7) mol/l) also stimulated insulin release.
Positive_regulation (stimulated) of Localization (release) of insulin associated with morphine
4) Confidence 0.69 Published 1980 Journal Diabetologia Section Abstract Doc Link 6998819 Disease Relevance 0 Pain Relevance 1.30
The insulin secretory response of perifused islets to enkephalins and morphine was rapid, corresponding to the first phase of glucose induced insulin release.
Positive_regulation (induced) of Localization (release) of insulin associated with enkephalin and morphine
5) Confidence 0.69 Published 1980 Journal Diabetologia Section Abstract Doc Link 6998819 Disease Relevance 0 Pain Relevance 1.30
In order to settle the question about whether or not opioid peptides stimulate or inhibit insulin secretion, we studied effects of rimorphin and dynorphin, two members of the preproenkephalin B group, on glucose-induced insulin secretion in the isolated, perfused rat pancreas.
Positive_regulation (induced) of Localization (secretion) of insulin in pancreas associated with dynorphin and opioid
6) Confidence 0.69 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.44
Glutamate stimulates insulin secretion and improves glucose tolerance in rats.
Positive_regulation (stimulates) of Localization (secretion) of insulin associated with glutamate, tolerance and impaired glucose tolerance
7) Confidence 0.69 Published 1995 Journal Am. J. Physiol. Section Title Doc Link 7573433 Disease Relevance 0.28 Pain Relevance 0.60
Dihydroergotamine, but not naloxone, counteracts lithium as an inhibitor of glucose-induced insulin release in isolated rat islets in vitro.
Positive_regulation (induced) of Localization (release) of insulin associated with narcan
8) Confidence 0.69 Published 1987 Journal Diabetologia Section Title Doc Link 3556290 Disease Relevance 0 Pain Relevance 0.25
However, in the serum of rats during hyperthermia (rectal temperature 40-41 degrees C) the glucose level was about 52% lower and FFA were about 39% lower than in rats kept under normothermic conditions (rectal temperature 36.5-37.5 degrees C) which may point to an increased requirement of tissues for energy-yielding substrates at higher body temperatures and/or increased insulin secretion.
Positive_regulation (requirement) of Localization (secretion) of insulin in body associated with hyperinsulinism and fever
9) Confidence 0.69 Published 1984 Journal Acta Physiol Pol Section Abstract Doc Link 6537718 Disease Relevance 0.35 Pain Relevance 0
Nalmefene given intragestrically attenuated glucose-stimulated increases in insulin release only in obese rats.
Positive_regulation (increases) of Localization (release) of insulin associated with obesity
10) Confidence 0.69 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 2947253 Disease Relevance 0.58 Pain Relevance 0.43
None of these agents restored insulin release.
Positive_regulation (restored) of Localization (release) of insulin
11) Confidence 0.69 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6338738 Disease Relevance 0 Pain Relevance 0.13
The inhibitory effect of rimorphin was attenuated by naloxone (1.2 X 10(-6) M) and phentolamine (10(-6) M), suggesting an involvement of adrenergic alpha receptors in the inhibition of glucose-induced insulin secretion mediated through specific opiate receptors.
Positive_regulation (induced) of Localization (secretion) of insulin associated with narcan and opiate
12) Confidence 0.69 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.48
Rimorphin also inhibited glucose-induced insulin secretion even in the cysteamine-treated rat pancreas from which somatostatin had been depleted.
Positive_regulation (induced) of Localization (secretion) of insulin in pancreas associated with somatostatin
13) Confidence 0.69 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.47
In anesthetized fasted rats, glutamate at 9 mg/kg was ineffective, but during an intravenous glucose tolerance test (0.5 g/kg), glutamate markedly potentiated insulin release and increased the glucose disappearance rate.
Positive_regulation (potentiated) of Localization (release) of insulin associated with glutamate, tolerance and impaired glucose tolerance
14) Confidence 0.69 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7573433 Disease Relevance 0.33 Pain Relevance 0.65
The results showed that noradrenaline injection into MPOA produced a rapid increase in plasma glucose levels and insulin secretion, reaching a peak at 15 min post stimulus (25% over basal, P<0.01) for plasma glucose and at 30 min for insulin secretion (94% over basal, P<0.05).
Positive_regulation (increase) of Localization (secretion) of insulin in plasma associated with noradrenaline and urological neuroanatomy
15) Confidence 0.69 Published 2003 Journal Brain Res. Section Abstract Doc Link 12957368 Disease Relevance 0.61 Pain Relevance 0.45
CONCLUSIONS: We conclude that the acute demand for insulin secretion induced by a 50% partial pancreatectomy is not necessarily associated with an acute increase in islet blood perfusion.
Spec (partial) Positive_regulation (induced) of Localization (secretion) of insulin in blood
16) Confidence 0.69 Published 2005 Journal Pancreas Section Body Doc Link 15632702 Disease Relevance 0 Pain Relevance 0
The direct effect of lithium administration on plasma glucose levels and glucose-induced insulin release, and the role of opioid and amine systems in these effects were examined in rats.
Spec (examined) Positive_regulation (induced) of Localization (release) of insulin in plasma associated with opioid
17) Confidence 0.69 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 2870599 Disease Relevance 0.15 Pain Relevance 0.32
The results suggest that the interaction of secreted endorphins with the sympathetic nervous system is the likely cause of the hyperglycaemia and the inhibition of the glucose-stimulated insulin release induced by lithium.
Positive_regulation (induced) of Localization (release) of insulin in sympathetic nervous system
18) Confidence 0.69 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 2870599 Disease Relevance 0.17 Pain Relevance 0.28
Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%.
Neg (failed) Positive_regulation (induced) of Localization (release) of insulin
19) Confidence 0.69 Published 1987 Journal Diabetologia Section Abstract Doc Link 3556290 Disease Relevance 0 Pain Relevance 0.19
Naloxone, an opiate antagonist, and dihydroergotamine, an alpha-adrenergic blocking agent, reversed the hyperglycaemia as well as the inhibition of glucose-stimulated insulin release induced by lithium.
Positive_regulation (induced) of Localization (release) of insulin associated with antagonist, narcan and opiate
20) Confidence 0.69 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 2870599 Disease Relevance 0.17 Pain Relevance 0.32

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