INT198870

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.47
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gpx3) oxidoreductase activity (Gpx3) extracellular region (Gpx3)
Anatomy Link Frequency
choroid plexus 1
brain 1
extracellular matrix 1
Gpx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 108 99.04 Very High Very High Very High
Inflammation 79 98.72 Very High Very High Very High
Pain 1 78.16 Quite High
imagery 85 75.60 Quite High
unmyelinated 1 74.80 Quite High
Neuritis 31 71.60 Quite High
Hippocampus 2 12.92 Low Low
Multiple sclerosis 30 11.36 Low Low
Spinal cord 30 5.00 Very Low Very Low Very Low
long-term potentiation 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 215 99.70 Very High Very High Very High
INFLAMMATION 81 98.72 Very High Very High Very High
Adhesions 26 94.16 High High
Multiple Sclerosis 137 84.48 Quite High
Bullous Skin Disease 39 84.20 Quite High
Skin Diseases 2 76.36 Quite High
Optic Neuritis 28 71.60 Quite High
Disease 133 70.72 Quite High
Autoimmune Disease 27 64.68 Quite High
Targeted Disruption 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial cells of the choroid plexus and other CVO express proteoglycans, fibronectin and other extracellular matrix proteins [33,34], which may bind Gf.
extracellular Binding (bind) of in choroid plexus
1) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.65 Pain Relevance 0.35
High binding affinity to plasma albumin and extracellular matrix proteins may explain the delayed initial CNS tissue accumulation but also the persisting presence of Gf within the brain parenchyma for up to 10 days [9,18].
extracellular Binding (affinity) of in brain associated with central nervous system
2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.50 Pain Relevance 0.31
This analysis likely underestimated the association of extracellular space with microglial processes because of the partial penetration of antibodies under these stringent immunocytochemical conditions.
extracellular Binding (association) of
3) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0
Desmogleins and desmocollins are transmembrane glycoproteins that are thought to establish cell coupling via binding of their extracellular domains.
extracellular Binding (binding) of
4) Confidence 0.01 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.91 Pain Relevance 0.08
Freeze-fracture data of AQP4-containing membranes, along with the identification of AQP4-specific antibodies in NMO patients that bind extracellular AQP4 support the notion that parts of AQP4 are accessible on the outside of the cell [7,21,24].
extracellular Binding (bind) of associated with neuromyelitis optica
5) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.10 Pain Relevance 0.06
When proteolysis of these membrane proteins occurs, the cellular binding to the extracellular matrix is broken, allowing a cell to migrate, or allowing portions of a cell to form new interactions.
extracellular Binding (binding) of in extracellular matrix
6) Confidence 0.00 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.31 Pain Relevance 0

General Comments

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