INT198875

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp23) endoplasmic reticulum (Mmp23)
Anatomy Link Frequency
neutrophil 1
Mmp23 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 85 100.00 Very High Very High Very High
unmyelinated 1 77.44 Quite High
Spinal cord 1 75.32 Quite High
cytokine 19 69.92 Quite High
Inflammation 19 65.52 Quite High
Peripheral nervous system 2 14.32 Low Low
Pain 2 8.00 Low Low
rheumatoid arthritis 38 5.00 Very Low Very Low Very Low
long-term potentiation 24 5.00 Very Low Very Low Very Low
Osteoarthritis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloid Plaque 18 99.64 Very High Very High Very High
Targeted Disruption 26 98.40 Very High Very High Very High
Alzheimer's Dementia 50 97.36 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 21 92.88 High High
Creutzfeldt Jakob Disease 1 89.16 High High
Disease 88 88.20 High High
Huntington's Chorea 2 86.16 High High
Neurodegenerative Disease 4 85.08 High High
Apoptosis 6 71.52 Quite High
Cancer 8 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from those included in these main groups, other MMPs have been described including MMP-12 (metalloelastase), MMP-19, MMP-20 (enamelysin), MMP-20 and MMP-23, as well as XMMP (Xenopus) and CMMP (chicken) [19] (for review, see [20]).
Localization (metalloelastase) of MMP-23 associated with metalloproteinase
1) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.27 Pain Relevance 0.34
Doxycycline shown as a TTR fibril disrupter in vitro [9], when tested in transgenic TTR V30M mice, was capable of disaggregating amyloid deposits with concomitant decrease of metalloproteinase 9 (MMP-9), tissue inhibitor of metalloproteinase (TIMP-1), serum amyloid P component (SAP) and neutrophil gelatinase-associated lipocalin NGAL [10,11].
Localization (decrease) of metalloproteinase in neutrophil associated with targeted disruption, alzheimer's dementia, metalloproteinase and amyloid plaque
2) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.48 Pain Relevance 0.24
Extracellular proteinases responsible for the release of soluble receptors are commonly metalloproteinases, either membrane bound (A Disintegrin and Metalloproteinase, ADAMs) or secreted (Matrix Metalloproteinase, MMPs) [137].
Localization (secreted) of Metalloproteinase associated with metalloproteinase
3) Confidence 0.01 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.15 Pain Relevance 0.15
Extracellular proteinases responsible for the release of soluble receptors are commonly metalloproteinases, either membrane bound (A Disintegrin and Metalloproteinase, ADAMs) or secreted (Matrix Metalloproteinase, MMPs) [137].
Localization (secreted) of Metalloproteinase associated with metalloproteinase
4) Confidence 0.01 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

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