INT198883

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Lrpap1) plasma membrane (Lrpap1) cytoplasm (Lrpap1)
Anatomy Link Frequency
reticulum 1
Lrpap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 38 100.00 Very High Very High Very High
cytokine 11 27.20 Quite Low
chemokine 6 26.48 Quite Low
long-term potentiation 24 5.00 Very Low Very Low Very Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
nMDA receptor 10 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 43 100.00 Very High Very High Very High
Apoptosis 1 99.58 Very High Very High Very High
Aging 64 96.76 Very High Very High Very High
Drug Induced Neurotoxicity 4 60.12 Quite High
Disease 73 44.04 Quite Low
Dementia 2 43.28 Quite Low
Injury 2 41.64 Quite Low
Pathologic Processes 3 36.68 Quite Low
Targeted Disruption 18 36.64 Quite Low
Alzheimer's Dementia 18 35.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B pathway, such as STAT1 and TLR1; cell proliferation/apoptosis, such as IER3; EHF; LRPAP1 and inflammation such as CCL7; CXCL16; B2M; IL7R and LGALS3 were among the genes whose transcripts were increased in the context of both in vivo aging and in vitro senescence.
LRPAP1 Binding (were) of associated with aging, inflammation and apoptosis
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.70 Pain Relevance 0.05
RAP is an endoplasmic reticulum (ER)-resident protein that functions in receptor folding and trafficking along the early secretory pathway and universally antagonizes ligand-binding to all members of the family [69].
RAP Binding (ligand-binding) of in reticulum
2) Confidence 0.10 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.06 Pain Relevance 0
A common feature that is shared by most members of the LDLR family is their ability to bind the receptor-associated protein (RAP) [69].
RAP Binding (bind) of
3) Confidence 0.10 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.06 Pain Relevance 0

General Comments

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