INT198884

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 2.41
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vldlr) extracellular space (Vldlr) nucleus (Vldlr)
lipid metabolic process (Vldlr)
Anatomy Link Frequency
microglia 3
liver 2
neuronal 1
hepatocyte 1
granulosa cells 1
Vldlr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 40 96.88 Very High Very High Very High
Bile 21 95.00 High High
nMDA receptor 25 87.52 High High
Inflammation 10 56.52 Quite High
glial activation 5 39.20 Quite Low
antagonist 5 24.24 Low Low
long-term potentiation 60 21.28 Low Low
Dopamine 1 10.20 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
isoflurane 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 96 96.36 Very High Very High Very High
Lipodystrophy 12 95.80 Very High Very High Very High
Cytomegalovirus Infection 15 95.48 Very High Very High Very High
Hyperlipidemia 57 88.20 High High
Hyperlipoproteinemia Type Ii 132 87.68 High High
Death 18 86.68 High High
Atherosclerosis 66 80.96 Quite High
Targeted Disruption 104 78.04 Quite High
Syndrome 13 69.24 Quite High
Ectodermal Dysplasia 1 68.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was further supported by the expression analysis of genes such as VldlR and Lpin1 that start to be expressed at 2.5 dpp (this study).
Gene_expression (expression) of VldlR
1) Confidence 0.70 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.17 Pain Relevance 0
In Kit mutants, a defective hepatic metabolism, with the abnormal low expression of VldlR and Lpin1, leads to the maintenance of this "transient steatosis".
Gene_expression (expression) of VldlR
2) Confidence 0.70 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.12 Pain Relevance 0
In addition Vldlr expression appeared to be significantly retarded at 1.5 dpp just during the transient steatosis while the expression level reached a plateau at 2.5 dpp with the same expression level found at 10.5 dpp.
Gene_expression (expression) of Vldlr
3) Confidence 0.61 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.08 Pain Relevance 0.04
This was further supported by the expression analysis of genes such as VldlR and Lpin1 that start to be expressed at 2.5 dpp (this study).
Gene_expression (expression) of VldlR
4) Confidence 0.60 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.17 Pain Relevance 0
Two genes involved in metabolism, StAR and Vldlr, are expressed in granulosa cells and the gene products of both are involved in steroidogenesis.
Gene_expression (expressed) of Vldlr in granulosa cells
5) Confidence 0.55 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.26 Pain Relevance 0
Expression of most of the genes remained unchanged in wild-type and mutant individuals at 10.5 dpp (not shown) except for the very low density lipoprotein receptor (Vldlr), the Lpin1 and the lipoprotein lipase (Lpl) genes that were downregulated in Sco5/Sco5 mutants compared to wild-type littermates (Figure 6).
Gene_expression (Expression) of Vldlr
6) Confidence 0.54 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.10 Pain Relevance 0.05
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Spec (determined) Gene_expression (expression) of VldlR in bile associated with bile and lipodystrophy
7) Confidence 0.54 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.16 Pain Relevance 0.05
Neurons express LDLR, LRP, ApoER2, and the VLDLR; astrocytes express LDLR and LRP; microglia express VLDLR and LRP [6,57,70-73].
Gene_expression (express) of VLDLR in microglia
8) Confidence 0.41 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0
Neurons express LDLR, LRP, ApoER2, and the VLDLR; astrocytes express LDLR and LRP; microglia express VLDLR and LRP [6,57,70-73].
Gene_expression (express) of VLDLR in microglia
9) Confidence 0.35 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0
VLDLR and ApoER2 transduce signals from the extracellular matrix molecule Reelin, affecting neuronal cell migration during development [83].
Gene_expression (transduce) of VLDLR in neuronal
10) Confidence 0.35 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.04
Neurons express LDLR, LRP, ApoER2, and the VLDLR; astrocytes express LDLR and LRP; microglia express VLDLR and LRP [6,57,70-73].
Gene_expression (express) of VLDLR in microglia
11) Confidence 0.35 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0
Soluble ApoER2 and VLDLR
Gene_expression (Soluble) of VLDLR
12) Confidence 0.35 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.19
Western blot analysis and immunohistochemistry revealed high levels of VLDLR expression in approximately 2-5% of cells of liver harvested at 3 and 6 months after vector delivery with a low vector DNA copy number of 1 copy/cell.
Gene_expression (expression) of VLDLR in liver
13) Confidence 0.32 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.51 Pain Relevance 0
In an attempt to address this issue, Jacobs and colleagues investigated the use of a relatively low dose (5 × 1010 particles) of second generation E1E3E4-deleted adenoviral vectors for transfer of the LDLR or VLDLR, under control of the hepatocyte-specific human ?
Gene_expression (transfer) of VLDLR in hepatocyte
14) Confidence 0.24 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.43 Pain Relevance 0.03
Briefly, it is involved in the hepatic uptake and subsequent degradation of lipoproteins through the LDL-R on parenchymal liver cells, clearance of chylomicron remnants through the action of LDL-R related proteins, the stimulation of hepatic VLDL and TG production, reverse cholesterol transport (the process whereby excess cholesterol is transported via HDL to the liver for excretion in bile) and activation of enzymes, such as hepatic lipase and cholesteryl ester transfer protein, involved in lipoprotein metabolism.
Gene_expression (production) of hepatic VLDL in liver associated with bile and disorder of lipid metabolism
15) Confidence 0.01 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975993 Disease Relevance 0.41 Pain Relevance 0.05

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