INT198888

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.44
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Apoc4) extracellular region (Apoc4)
Anatomy Link Frequency
macrophages 3
neurons 1
brains 1
astrocytes 1
embryonic stem cells 1
Apoc4 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 65 99.60 Very High Very High Very High
long-term potentiation 36 98.68 Very High Very High Very High
cytokine 136 98.60 Very High Very High Very High
Inflammation 133 98.40 Very High Very High Very High
Inflammatory response 40 96.40 Very High Very High Very High
Intracerebroventricular 5 88.16 High High
anesthesia 3 82.24 Quite High
nMDA receptor 15 80.32 Quite High
chemokine 5 60.04 Quite High
antagonist 3 42.60 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 49 99.98 Very High Very High Very High
Osteoarthritis 65 99.60 Very High Very High Very High
Disorder Of Lipid Metabolism 304 99.06 Very High Very High Very High
INFLAMMATION 186 98.40 Very High Very High Very High
Drug Induced Neurotoxicity 6 96.90 Very High Very High Very High
Cardiovascular Disease 38 92.92 High High
Cancer 10 92.16 High High
Necrosis 10 91.60 High High
Toxicity 6 91.32 High High
Cognitive Disorder 3 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first patient group consisted of patients with mild OA, who had undergone ACL reconstruction between 1994 and 1996.
Gene_expression (reconstruction) of ACL associated with osteoarthritis
1) Confidence 0.27 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2289810 Disease Relevance 0.36 Pain Relevance 0.18
(Fig. 1A and B), there was a tendency for apoE4 expressing cells to secrete higher levels of cytokines at the majority of LPS concentrations tested, although the inter-group differences did not reach statistical significance (Fig. 1A and B).
Gene_expression (expressing) of apoE4 associated with cytokine
2) Confidence 0.05 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.06 Pain Relevance 0.27
The murine monocyte–macrophage cell line (RAW 264.7) stably transfected to produce equal amounts of human apoE3 or apoE4 was used.
Gene_expression (produce) of apoE4 in macrophage
3) Confidence 0.04 Published 2007 Journal Biochemical and Biophysical Research Communications Section Abstract Doc Link PMC2096715 Disease Relevance 0.96 Pain Relevance 0.21
In contrast apoE4-macrophages produced 99%, 62%, 54%, and 83% more TNF?
Gene_expression (produced) of apoE4-macrophages in macrophages
4) Confidence 0.04 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.09 Pain Relevance 0.35
observed in apoE4 macrophages were partly due to decreased levels of IL10 or due to other mechanisms cannot be concluded.
Gene_expression (macrophages) of apoE4 in macrophages
5) Confidence 0.04 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 1.15 Pain Relevance 0.68
By using transgenic mice expressing human apoE3 or apoE4, Lynch et al. [14] determined that apoE4 mice showed elevated systemic and brain pro-inflammatory cytokines following intravenous administration of LPS, and Ophir et al. [12] demonstrated that the expression of inflammation genes was higher and more prolongated in the brains of apoE4 following intracerebroventricular injection of LPS.
Gene_expression (expressing) of apoE4 in brains associated with targeted disruption, inflammation, intracerebroventricular and cytokine
6) Confidence 0.04 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 1.03 Pain Relevance 0.64
In contrast, mice expressing the apoE4 isoform demonstrate compromised LTP induction and spatial learning.
Gene_expression (expressing) of apoE4 associated with long-term potentiation
7) Confidence 0.02 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.27 Pain Relevance 0.18
42-induced neurotoxicity is significantly greater in both Neuro-2A cells treated with apoE4 [112-114] and primary co-cultures of wild-type (WT) neurons and glia from apoE-TR mice expressing apoE4 [47,112].
Gene_expression (expressing) of apoE4 in neurons associated with drug induced neurotoxicity
8) Confidence 0.02 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.49 Pain Relevance 0.22
Transgenic expression of human apoE4 has dominant negative behavioral effects [103-106], including deficits in memory tasks [103,105].
Gene_expression (expression) of apoE4 associated with targeted disruption
9) Confidence 0.02 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.43 Pain Relevance 0.24
Postnatal day 2 mice that possess the homozygous epsilon 3 (3/3) or epsilon 4 (4/4) allele, and correctly expressing human apoE3 or apoE4 proteins, respectively, were used in this study.


Gene_expression (expressing) of apoE4
10) Confidence 0.02 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.24 Pain Relevance 0.08
Preparation of HDL released into conditioned media of astrocytes expressing apoE3 or apoE4
Gene_expression (expressing) of apoE4 in astrocytes associated with disorder of lipid metabolism
11) Confidence 0.02 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.10 Pain Relevance 0.05
Mice expressing human apoE4 in place of mouse apoE were generated by the gene-targeting technique taking advantage of homologous recombination in embryonic stem cells (knock-in) as previously described [34].
Gene_expression (expressing) of apoE4 in embryonic stem cells associated with targeted disruption
12) Confidence 0.01 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.26 Pain Relevance 0

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