INT198889

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.60
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lrp1) endosome (Lrp1) plasma membrane (Lrp1)
nucleus (Lrp1) cytoplasm (Lrp1)
Anatomy Link Frequency
cleavage 4
Lrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 90.64 High High
Central nervous system 28 51.60 Quite High
Inflammation 50 51.28 Quite High
cytokine 20 40.96 Quite Low
Inflammatory response 10 28.32 Quite Low
sodium channel 13 13.72 Low Low
ischemia 31 5.00 Very Low Very Low Very Low
Peripheral nervous system 26 5.00 Very Low Very Low Very Low
cINOD 25 5.00 Very Low Very Low Very Low
Hippocampus 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 12 98.72 Very High Very High Very High
Alzheimer's Dementia 140 92.76 High High
Disease 381 77.80 Quite High
Hypercholesterolemia 15 68.36 Quite High
Drug Induced Neurotoxicity 7 53.92 Quite High
INFLAMMATION 67 51.28 Quite High
Adhesions 11 21.44 Low Low
Targeted Disruption 173 5.00 Very Low Very Low Very Low
Stress 145 5.00 Very Low Very Low Very Low
Cognitive Disorder 90 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase cleavage of LRP enables release of the LRP-intracellular domain (LRP-ICD).
Protein_catabolism (cleavage) of LRP in cleavage
1) Confidence 0.68 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.46 Pain Relevance 0
Recent studies have also shown that the cell associated fragment of LRP can be cleaved at a third, intramembranous site by the ?
Protein_catabolism (cleaved) of LRP
2) Confidence 0.63 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.22
-secretase LRP cleavage and release of the LRP-ICD.
Protein_catabolism (cleavage) of LRP in cleavage
3) Confidence 0.44 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.40 Pain Relevance 0.05
-secretase cleavage of LRP enables release of the LRP-intracellular domain (LRP-ICD).
Protein_catabolism (cleavage) of LRP in cleavage
4) Confidence 0.36 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.24 Pain Relevance 0
subunit, LRP is processed in manner analogous to APP, at least in vitro.
Protein_catabolism (processed) of LRP
5) Confidence 0.27 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.26 Pain Relevance 0
-secretase LRP cleavage and release of the LRP-ICD.
Protein_catabolism (cleavage) of LRP in cleavage
6) Confidence 0.23 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.24 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox