INT198892

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.94
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
Macrophages 2
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1 92.92 High High
nMDA receptor 15 92.40 High High
Inflammation 36 88.72 High High
Multiple sclerosis 6 61.00 Quite High
cytokine 23 47.04 Quite Low
Thalamus 8 29.60 Quite Low
long-term potentiation 44 20.80 Low Low
Central nervous system 3 18.36 Low Low
dexamethasone 46 5.00 Very Low Very Low Very Low
metalloproteinase 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 8 99.48 Very High Very High Very High
Disease 150 98.72 Very High Very High Very High
Targeted Disruption 217 95.20 Very High Very High Very High
Amyloid Plaque 47 94.96 High High
Alzheimer's Dementia 187 93.76 High High
INFLAMMATION 41 88.72 High High
Disorder Of Lipid Metabolism 27 70.68 Quite High
Diabetes Mellitus 2 64.00 Quite High
Alcoholic Liver Cirrhosis 1 62.68 Quite High
Demyelinating Disease 2 61.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Macrophages of apoE-deficient mice stimulated by exogenous antigen are more effective in the upregulating of main histocompatibility complex (MHC) class II molecules and costimulatory molecules like CD40 and CD80, with increased IFN-?
Regulation (effective) of apoE Binding (Macrophages) of in Macrophages
1) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.38 Pain Relevance 0.05
Thus, the interactions of apoE complexes with the apoE receptors in the CNS vitally affect not only the metabolism of apoE, but of A?
Regulation (affect) of apoE Binding (interactions) of
2) Confidence 0.44 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.51 Pain Relevance 0
It allows the internalization of several ligands such as ApoE, APP (with the Kunitz inhibitor) and ?
Regulation (internalization) of ApoE Binding (ligands) of
3) Confidence 0.35 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.83 Pain Relevance 0.09
Thus, specific apoE receptor shedding may represent a novel mechanism for modulating individual apoE receptor-ligand interactions and overall apoE receptor function.


Regulation (modulating) of apoE receptor Binding (interactions) of
4) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0
The effect on apoE-dependent signaling has yet to be determined, but these studies suggest that selected apoE receptor shedding would affect both specific ligand binding, as in the case of soluble ApoER2 and Reelin signaling, as well as overall apoE binding and signaling.
Regulation (affect) of apoE Binding (binding) of
5) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.05
In consideration of the putative association of ApoE ?
Regulation (consideration) of ApoE Binding (association) of
6) Confidence 0.15 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 1.23 Pain Relevance 0.03

General Comments

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