INT198894

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 7 88.52 High High
metalloproteinase 8 71.52 Quite High
Catechol-O-methyltransferase 2 30.76 Quite Low
alcohol 2 10.32 Low Low
long-term potentiation 12 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
antidepressant 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 200 98.08 Very High Very High Very High
Alzheimer's Dementia 23 93.84 High High
Targeted Disruption 13 19.16 Low Low
Cognitive Disorder 56 5.00 Very Low Very Low Very Low
Dementia 35 5.00 Very Low Very Low Very Low
Vascular Dementia 16 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 13 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Psychosis 8 5.00 Very Low Very Low Very Low
Frailty 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Soluble apoE receptors
Regulation (Soluble) of Gene_expression (receptors) of apoE
1) Confidence 0.44 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.18 Pain Relevance 0.10
Several studies indicate that the presence of the APOE-4 allele differentially affects the quality and size of drug responsiveness in AD patients treated with cholinergic enhancers (tacrine, donepezil, rivastigmine) (Poirier 1999; Poirier et al 1995; Almqvist et al 2001).
Regulation (affects) of Gene_expression (presence) of APOE-4 allele associated with disease
2) Confidence 0.27 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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