INT198898

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.49
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gpx3) oxidoreductase activity (Gpx3) extracellular region (Gpx3)
Anatomy Link Frequency
extracellular matrix 3
spines 1
Cleavage 1
Gpx3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 36 98.66 Very High Very High Very High
Inflammation 50 95.08 Very High Very High Very High
wide dynamic range 1 81.48 Quite High
Bioavailability 2 80.48 Quite High
gABA 7 78.00 Quite High
Central nervous system 2 74.76 Quite High
fibrosis 38 60.20 Quite High
Inflammatory response 8 43.80 Quite Low
imagery 30 31.56 Quite Low
GABAergic 8 20.64 Low Low
Disease Link Frequency Relevance Heat
Cancer 102 99.66 Very High Very High Very High
Injury 48 96.40 Very High Very High Very High
INFLAMMATION 57 95.08 Very High Very High Very High
Disease 48 93.84 High High
Targeted Disruption 17 92.60 High High
Pancreatic Cancer 59 92.40 High High
Pancreatitis 12 89.52 High High
Adhesions 10 82.40 Quite High
Fibrosis 52 79.36 Quite High
Apoptosis 4 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although MMPs were traditionally viewed as molecules that were only involved in degradation and turnover of the extracellular matrix, novel insights overturned this dogma and revealed that MMPs modulate the activities of a wide range of extracellular and intracellular signaling pathways [22], [23].
Protein_catabolism (degradation) of extracellular in extracellular matrix associated with metalloproteinase
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.99 Pain Relevance 0.56
In the event of pathological insult, microglia rapidly become activated, thicken and retract their processes, migrate to the site of injury, proliferate, and participate in the presentation of antigens, phagocytosis of cellular debris, and secretion of proteases that promote microglial motility, as well as myelin and extracellular matrix degradation [5]–[7].
Protein_catabolism (degradation) of extracellular in extracellular matrix associated with injury
2) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0.18 Pain Relevance 0.04
Among those, MMP2 and its inhibitor TIMP1 are known to be involved in tumor progression and extracellular matrix degradation [37].
Protein_catabolism (degradation) of extracellular in extracellular matrix associated with cancer
3) Confidence 0.01 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 0.95 Pain Relevance 0.08
In contrast to mCCRL2/L1.2 transfectants, however, at the 60-min time point there was a considerable reduction in surface-bound chemerin (Fig. 8 D, PBS wash), suggesting either eventual extracellular degradation or chemerin release.
Protein_catabolism (degradation) of extracellular
4) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
Degradation of the extracellular matrix with the tPA/plasminogen proteolytic cascade prevents the loss of superficial spines normally induced by 4 days of MD (Mataga et al. 2004)—an effect that is not observed in tPA knockout mice. tPA application also mimics the enhancement of spine dynamics seen after brief (2 days) MD (Oray et al. 2004).
Protein_catabolism (Degradation) of extracellular in spines associated with targeted disruption
5) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.09 Pain Relevance 0.04
Cleavage at the cell surface would release soluble proteins for extracellular degradation or clearance.
Protein_catabolism (degradation) of extracellular in Cleavage
6) Confidence 0.01 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.28 Pain Relevance 0

General Comments

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