INT198900

Context Info Confidence 0.26 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.44 Pain Relevance 0.12

transport (Vldlr) extracellular space (Vldlr) nucleus (Vldlr) lipid metabolic process (Vldlr)

Anatomy Link Frequency plasma 1 Vldlr (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 8 91.32 agonist 3 25.36 long-term potentiation 12 5.00 Bile 7 5.00 nMDA receptor 5 5.00 tolerance 5 5.00 cytokine 3 5.00 Inflammation 3 5.00 dexamethasone 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 38 100.00 Hyperlipoproteinemia Type Ii 66 95.12 Coagulation Disorder 6 92.88 Atherosclerosis 43 90.48 Fetal Nutrition Disorders 1 63.24 Hyperlipidemia 23 52.44 Pressure And Volume Under Development 29 50.00 Targeted Disruption 28 48.40 Disease 48 45.04 Cancer 7 23.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ApoER2 and VLDLR proteolytic events are also increased by extracellular ligand binding [148].

Positive_regulation (increased) of VLDLR

1) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.12

In addition to the LDLR gene augmentation approach, the successful use of the VLDLR as an effective surrogate lipoprotein receptor gene [139-141,153,216,217] for the complementation of mutated LDLR function in homozygote FH patients would also open an alternative therapeutic avenue, since it would avoid the immune problem in patients with no natural LDLR.

Positive_regulation (effective) of VLDLR associated with hyperlipoproteinemia type ii

2) Confidence 0.17 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.48 Pain Relevance 0

Moreover, the analysis of plasma HDL-cholesterol concentration showed a similar increase for animals of the C-OB and LP-OB group indicating that the higher values of total cholesterol observed in LP-OB mice were due to increased amount of LDL- and VLDL-cholesterol.

Positive_regulation (increase) of VLDL-cholesterol in plasma associated with disorder of lipid metabolism

3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 0.96 Pain Relevance 0

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