INT198921

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.70
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (App, Lrp1) plasma membrane (App, Lrp1) endosome (Lrp1)
Golgi apparatus (App) extracellular matrix organization (App) DNA binding (App)
Anatomy Link Frequency
plasma 1
App (Mus musculus)
Lrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 50.88 Quite High
long-term potentiation 28 11.12 Low Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
Kinase C 24 5.00 Very Low Very Low Very Low
nMDA receptor 14 5.00 Very Low Very Low Very Low
sodium channel 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 218 98.72 Very High Very High Very High
Targeted Disruption 54 91.96 High High
Endometriosis (extended) 4 84.16 Quite High
Alzheimer's Dementia 38 84.08 Quite High
INFLAMMATION 8 50.88 Quite High
Pathologic Processes 2 48.92 Quite Low
Adhesions 24 5.00 Very Low Very Low Very Low
Syndrome 22 5.00 Very Low Very Low Very Low
Amyloid Plaque 22 5.00 Very Low Very Low Very Low
Congenital Anomalies 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low-density lipoprotein receptor-related protein (LRP) is a SorLA/LR11-related protein that binds to APP through Fe65, a cytoplasmic adaptor protein [184].
APP Binding (binds) of LRP
1) Confidence 0.32 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.43 Pain Relevance 0
LRP interacts with APP through the intracellular adaptor protein FE65 or via direct binding to the KPI domain [90,123-126].
APP Binding (interacts) of LRP
2) Confidence 0.32 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.30 Pain Relevance 0
Antagonizing the extracellular interaction between cell-surface APP and LRP increased the level of cell surface APP while decreasing A?
APP Binding (interaction) of LRP
3) Confidence 0.30 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.52 Pain Relevance 0
Low-density lipoprotein receptor-related protein (LRP) is a SorLA/LR11-related protein that binds to APP through Fe65, a cytoplasmic adaptor protein [184].
APP Binding (binds) of receptor-related protein
4) Confidence 0.28 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.44 Pain Relevance 0
An LRP-related protein 1B (LRP1B) has a similar effect, binding APP at the plasma membrane, preventing APP internalization, and leading to decreased A?
APP Binding (binding) of LRP in plasma
5) Confidence 0.28 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.71 Pain Relevance 0.03
LRP interacts with APP through the intracellular adaptor protein FE65 or via direct binding to the KPI domain [90,123-126].
APP Binding (binding) of LRP
6) Confidence 0.24 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.30 Pain Relevance 0

General Comments

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