INT198926

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.18
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Apbb1, Lrp1) nucleus (Apbb1, Lrp1) plasma membrane (Apbb1, Lrp1)
endosome (Lrp1) histone binding (Apbb1) extracellular matrix organization (Apbb1)
Anatomy Link Frequency
nucleus 2
Apbb1 (Mus musculus)
Lrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 11 66.40 Quite High
Inflammation 24 66.08 Quite High
cytokine 11 55.76 Quite High
Inflammatory response 4 43.12 Quite Low
long-term potentiation 26 11.12 Low Low
metalloproteinase 20 5.00 Very Low Very Low Very Low
nMDA receptor 12 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
cINOD 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 309 98.72 Very High Very High Very High
Targeted Disruption 101 91.96 High High
Alzheimer's Dementia 79 84.08 Quite High
Drug Induced Neurotoxicity 12 68.72 Quite High
INFLAMMATION 32 66.08 Quite High
Toxicity 12 65.96 Quite High
Pathologic Processes 2 48.92 Quite Low
Endometriosis (extended) 2 42.64 Quite Low
Adhesions 20 36.24 Quite Low
Hypercholesterolemia 6 34.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LRP-ICD has been shown to translocate to the nucleus and interact with Fe65 and Tip60, although whether this occurs under physiological conditions remains to be determined.
Fe65 Binding (interact) of LRP in nucleus
1) Confidence 0.12 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.39 Pain Relevance 0.12
Low-density lipoprotein receptor-related protein (LRP) is a SorLA/LR11-related protein that binds to APP through Fe65, a cytoplasmic adaptor protein [184].
Fe65 Binding (binds) of LRP
2) Confidence 0.11 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.43 Pain Relevance 0
Low-density lipoprotein receptor-related protein (LRP) is a SorLA/LR11-related protein that binds to APP through Fe65, a cytoplasmic adaptor protein [184].
Fe65 Binding (binds) of receptor-related protein
3) Confidence 0.09 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.44 Pain Relevance 0
LRP interacts with APP through the intracellular adaptor protein FE65 or via direct binding to the KPI domain [90,123-126].
FE65 Binding (interacts) of LRP
4) Confidence 0.09 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.30 Pain Relevance 0
LRP interacts with APP through the intracellular adaptor protein FE65 or via direct binding to the KPI domain [90,123-126].
FE65 Binding (binding) of LRP
5) Confidence 0.06 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.30 Pain Relevance 0
The LRP-ICD has been shown to translocate to the nucleus and interact with Fe65 and Tip60, although whether this occurs under physiological conditions remains to be determined.
Fe65 Binding (interact) of LRP in nucleus
6) Confidence 0.05 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.31 Pain Relevance 0.12

General Comments

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