INT198934

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.62
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
plasma 2
App (Mus musculus)
Lrp1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3 55.28 Quite High
long-term potentiation 14 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
nMDA receptor 7 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 109 92.84 High High
Endometriosis (extended) 2 88.56 High High
Targeted Disruption 27 69.08 Quite High
Alzheimer's Dementia 19 66.80 Quite High
INFLAMMATION 4 55.28 Quite High
Pathologic Processes 1 31.64 Quite Low
Neuroblastoma 2 7.92 Low Low
Adhesions 12 5.00 Very Low Very Low Very Low
Syndrome 11 5.00 Very Low Very Low Very Low
Amyloid Plaque 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An LRP-related protein 1B (LRP1B) has a similar effect, binding APP at the plasma membrane, preventing APP internalization, and leading to decreased A?
APP Binding (internalization) of LRP1B in plasma
1) Confidence 0.27 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.72 Pain Relevance 0.03
An LRP-related protein 1B (LRP1B) has a similar effect, binding APP at the plasma membrane, preventing APP internalization, and leading to decreased A?
APP Binding (binding) of LRP1B in plasma
2) Confidence 0.23 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.70 Pain Relevance 0.03
The apoE receptor LRP1B, which undergoes a slow endocytosis, interacts with APP.
APP Binding (interacts) of LRP1B
3) Confidence 0.18 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.19 Pain Relevance 0

General Comments

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