INT198952

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.68
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
vesicles 1
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 111 99.40 Very High Very High Very High
cocaine 119 99.32 Very High Very High Very High
addiction 20 98.80 Very High Very High Very High
monoamine 11 98.80 Very High Very High Very High
Eae 21 95.44 Very High Very High Very High
alcohol 4 89.68 High High
opiate 1 89.20 High High
Nucleus accumbens 10 77.20 Quite High
agonist 4 74.84 Quite High
midbrain 27 74.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 14 90.92 High High
Alcohol Addiction 1 90.08 High High
Attention Deficit Hyperactivity Disorder 5 84.88 Quite High
Death 5 68.64 Quite High
Parkinson's Disease 42 65.12 Quite High
Recurrence 2 55.48 Quite High
Drug Induced Neurotoxicity 1 49.96 Quite Low
Aggression 1 45.24 Quite Low
Disease 88 39.92 Quite Low
Aging 15 34.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that the blockade of DAT is required for cocaine induced reward and locomotor stimulation.
Localization (blockade) of DAT associated with cocaine
1) Confidence 0.75 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.30 Pain Relevance 0.80
DAT may contribute to the vulnerability of DA-cells serving as an entrance for DA and its metabolites, while VMAT2 may serve as a neuroprotective factor by sequestering DA into vesicles, and preventing interaction with their catabolic enzymes.
Localization (vulnerability) of DAT in vesicles
2) Confidence 0.27 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.18 Pain Relevance 0.13
For example, targeting the DAT should be useful in treating addiction to any Class III drug.
Localization (targeting) of DAT associated with addiction
3) Confidence 0.25 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0.20 Pain Relevance 0.68

General Comments

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