INT1990

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Context Info
Confidence 0.41
First Reported 1979
Last Reported 2004
Negated 2
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 38.05
Pain Relevance 28.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sciatic nerves 8
T-cell 4
peripheral nerve 3
macrophages 1
spleen 1
Ean5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 345 100.00 Very High Very High Very High
tolerance 75 99.78 Very High Very High Very High
Demyelination 12 99.50 Very High Very High Very High
Sciatic nerve 13 99.26 Very High Very High Very High
Inflammation 26 98.84 Very High Very High Very High
Spinal cord 6 93.16 High High
Central nervous system 1 82.08 Quite High
Peripheral nervous system 1 55.64 Quite High
cytokine 1 55.20 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 345 100.00 Very High Very High Very High
Disease 45 100.00 Very High Very High Very High
Immunization 63 99.84 Very High Very High Very High
Sprains And Strains 4 99.74 Very High Very High Very High
Paraparesis 2 99.60 Very High Very High Very High
Demyelinating Disease 29 99.50 Very High Very High Very High
Hypersensitivity 7 99.38 Very High Very High Very High
Vibrio Infection 16 99.32 Very High Very High Very High
Recurrence 1 98.92 Very High Very High Very High
INFLAMMATION 26 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that EAN induced by the P2-specific T-cell line can lead to a profound and rapidly evolving nerve dysfunction in a dose-dependent fashion.
Positive_regulation (induced) of EAN in nerve associated with neuritis
1) Confidence 0.41 Published 1986 Journal Ann. Neurol. Section Abstract Doc Link 2418761 Disease Relevance 0.61 Pain Relevance 0.52
For comparison, adoptive transfer experimental autoimmune neuritis (AT-EAN) of differing disease severity was induced by titrating the dose of P2-specific T-cells.
Positive_regulation (induced) of AT-EAN in T-cells associated with experimental autoimmune neuritis, disease and neuritis
2) Confidence 0.41 Published 2003 Journal Muscle Nerve Section Abstract Doc Link 12929195 Disease Relevance 1.29 Pain Relevance 0.87
EAN was induced by inoculation with bovine peripheral myelin.
Positive_regulation (induced) of EAN associated with neuritis
3) Confidence 0.41 Published 1992 Journal Intern. Med. Section Abstract Doc Link 1373661 Disease Relevance 0.77 Pain Relevance 0.77
Experimental allergic neuritis (EAN) was induced in guinea pigs and rats and treated with Cyclosporin-A (Cy-A).
Positive_regulation (induced) of EAN associated with experimental autoimmune neuritis and neuritis
4) Confidence 0.40 Published 1983 Journal Acta Neuropathol. Section Abstract Doc Link 6223482 Disease Relevance 0.55 Pain Relevance 0.47
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (induced) of EAN in sciatic nerves associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
5) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.60 Pain Relevance 1.31
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (induced) of EAN in sciatic nerves associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
6) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.61 Pain Relevance 1.32
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (induced) of EAN in sciatic nerves associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
7) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.57 Pain Relevance 1.30
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (induced) of EAN in sciatic nerves associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
8) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.60 Pain Relevance 1.33
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (induced) of EAN in sciatic nerves associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
9) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.60 Pain Relevance 1.33
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (induced) of EAN in mononuclear cell associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
10) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.49 Pain Relevance 1.21
Corresponding to the different clinical course, pathological changes and immune responses were found: (1) Onset of clinical signs of P0 peptide 56-71 (P0 56-71) induced EAN was 1-3 days later than in P0 peptide 180-199 (P0 180-199) induced EAN at all immunizing doses, whereas the peak of the disease occurred at a similar time point post immunization (p.i.), i.e. at days 14-16 p.i. in P0 56-71 induced EAN and at day 16 p.i. in P0 180-199 induced EAN. (2) Intramolecular epitope spreading as assessed by delayed type hypersensitivity response occurred in P0 56-71 induced EAN at both low and high antigen doses and in P0 180-199 induced EAN at high antigen dose (250 microg/rat) only. (3) P0 180-199 stimulated higher levels of interferon-gamma production in P0 180-199 induced EAN than in P0 56-71 induced EAN and vice versa. (4) Histopathologic evaluation revealed a similar grade of mononuclear cell infiltration in the sciatic nerves of both types of EAN, but more severe demyelination was found in P0 180-199 induced EAN compared to P0 56-71 induced EAN.
Positive_regulation (induced) of EAN in sciatic nerves associated with demyelination, hypersensitivity, immunization, sciatic nerve, disease and neuritis
11) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240020 Disease Relevance 1.56 Pain Relevance 1.30
Experimental allergic neuritis (EAN) was induced in Lewis rats by immunisation with bovine spinal root myelin.
Positive_regulation (induced) of EAN in spinal associated with experimental autoimmune neuritis, immunization and neuritis
12) Confidence 0.37 Published 1988 Journal J. Neuroimmunol. Section Abstract Doc Link 2459155 Disease Relevance 0.45 Pain Relevance 0.33
In adoptive transfer experiments this cell line did not induce EAN but did protect normal recipients from actively induced EAN.
Neg (not) Positive_regulation (induce) of EAN associated with neuritis
13) Confidence 0.37 Published 1988 Journal J. Neuroimmunol. Section Abstract Doc Link 2459155 Disease Relevance 0.59 Pain Relevance 0.42
Although the Lewis rat is far more susceptible to EAE caused by guinea pig CNS myelin than by any other species, EAN can be easily induced in this animal by injection of PNS myelin from a number of species.
Positive_regulation (induced) of EAN associated with multiple sclerosis and neuritis
14) Confidence 0.28 Published 1979 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 312920 Disease Relevance 0.90 Pain Relevance 0.60
Because DA-EAN is easily inducible and leads consistently to relapses in most rats, it can be used for studies of immune factors that determine a relapsing course of autoimmunity.
Positive_regulation (inducible) of DA-EAN associated with autoimmune disease, neuritis and recurrence
15) Confidence 0.26 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743436 Disease Relevance 1.97 Pain Relevance 0.90
The fact that development of actively induced EAN was not prevented or even mitigated by T cell vaccination, in spite of an apparent vaccination-induced response to and on T lymphocytes, suggests that protection from disease is not readily induced in every autoimmune disease model.
Positive_regulation (induced) of EAN in T lymphocytes associated with autoimmune disease, disease and neuritis
16) Confidence 0.22 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1720130 Disease Relevance 0.79 Pain Relevance 0.46
When injected i.v. into syngeneic recipients, BN P2-specific T cell lines induced both clinical and histologic signs of experimental allergic neuritis (EAN), overcoming the resistance of this rat strain to actively induced EAN.
Positive_regulation (induced) of EAN in T cell associated with experimental autoimmune neuritis, sprains and strains and neuritis
17) Confidence 0.19 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2431045 Disease Relevance 0.96 Pain Relevance 0.46
Likewise, severity of P2 53-78-induced EAN was not different between naive and T line-vaccinated groups.
Positive_regulation (induced) of EAN associated with neuritis
18) Confidence 0.18 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1720130 Disease Relevance 0.65 Pain Relevance 0.49
Vaccinated animals were not protected from EAN induced by immunization with P2 protein in complete Freund's adjuvant (CFA).
Positive_regulation (induced) of EAN associated with immunization and neuritis
19) Confidence 0.18 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1720130 Disease Relevance 0.66 Pain Relevance 0.47
The expression of tissue integrin alpha6beta4 was analyzed during the course of EAN induction and in controls by in situ hybridization and semi-quantitative RT-PCR.
Spec (analyzed) Positive_regulation (induction) of EAN
20) Confidence 0.13 Published 2003 Journal Zhonghua Bing Li Xue Za Zhi Section Body Doc Link 12882692 Disease Relevance 0.18 Pain Relevance 0

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