INT19900

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Context Info
Confidence 0.37
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 5.75
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
Blood 1
liver 1
pituitary 1
immune system 1
bowel 1
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 19 100.00 Very High Very High Very High
Somatostatin 10 100.00 Very High Very High Very High
Enkephalin 5 99.40 Very High Very High Very High
Morphine 7 98.78 Very High Very High Very High
narcan 8 98.64 Very High Very High Very High
cva 10 96.20 Very High Very High Very High
Pain 4 94.36 High High
tetrodotoxin 1 94.28 High High
antagonist 4 93.88 High High
Inflammatory mediators 2 93.64 High High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 5 100.00 Very High Very High Very High
Pituitary Cancer 4 100.00 Very High Very High Very High
Short Bowel Syndrome 38 99.84 Very High Very High Very High
Syndrome 18 99.32 Very High Very High Very High
Immunization 9 98.40 Very High Very High Very High
Growth Problems 10 96.52 Very High Very High Very High
Hemorrhage 10 96.20 Very High Very High Very High
Adhesions 6 95.84 Very High Very High Very High
Pain 3 94.36 High High
INFLAMMATION 42 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between clonidine and growth hormone releasing hormone in the stimulation of growth hormone secretion in man.
growth hormone Binding (interaction) of associated with clonidine
1) Confidence 0.37 Published 1990 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 2147600 Disease Relevance 0 Pain Relevance 0.58
One group received fentanyl 15 micrograms kg-1 i.v. immediately before the start of surgery; a second group received fentanyl 15 micrograms kg-1 i.v. together with corticotrophin releasing factor 100 micrograms i.v., growth hormone releasing hormone 100 micrograms i.v. and arginine vasopressin 10 units i.m.
growth hormone Binding (received) of
2) Confidence 0.37 Published 1990 Journal Br J Anaesth Section Abstract Doc Link 2223348 Disease Relevance 0 Pain Relevance 0.09
Growth hormone deficiency (GHD): a new association in Peters' Plus Syndrome (PPS).
Growth hormone Binding (association) of associated with syndrome and growth hormone deficiency
3) Confidence 0.37 Published 2004 Journal Am. J. Med. Genet. A Section Title Doc Link 14735587 Disease Relevance 1.06 Pain Relevance 0.08
We conclude that an increase in Ca2+ current is integral to the action of hGRF on these cells.
hGRF Binding (integral) of
4) Confidence 0.37 Published 1993 Journal Brain Res. Section Abstract Doc Link 8384513 Disease Relevance 0.16 Pain Relevance 0.14
The use of growth hormone is complex and raises many questions, including far reaching issues such as social perception of short stature (What is short stature?
growth hormone Binding (complex) of associated with growth problems
5) Confidence 0.31 Published 2010 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2856527 Disease Relevance 0.40 Pain Relevance 0
Influence of heterologous stimuli in birds refractory to human pancreatic growth hormone-releasing (hpGRF) or thyrotrophin releasing hormone (TRH).
thyrotrophin releasing hormone Binding (refractory) of
6) Confidence 0.30 Published 1985 Journal Gen. Comp. Endocrinol. Section Title Doc Link 3926600 Disease Relevance 0 Pain Relevance 0
Influence of heterologous stimuli in birds refractory to human pancreatic growth hormone-releasing (hpGRF) or thyrotrophin releasing hormone (TRH).
growth hormone Binding (refractory) of
7) Confidence 0.26 Published 1985 Journal Gen. Comp. Endocrinol. Section Title Doc Link 3926600 Disease Relevance 0 Pain Relevance 0
Immunization against GRF-HSA resulted in antibody titers, expressed as dilution required to bind 50% of [125I]GRF, ranging from 1:11,000 to 1:60,000 (wk 11 and 14); binding was not detectable or was less than 50% at 1:100 in HSA gilts (P less than .05).
GRF Binding (bind) of associated with immunization
8) Confidence 0.26 Published 1990 Journal J. Anim. Sci. Section Abstract Doc Link 2107160 Disease Relevance 0.40 Pain Relevance 0.09
Effects of the interaction between methysergide and clonidine on growth hormone and prolactin secretion in normal man.
growth hormone Binding (interaction) of associated with clonidine
9) Confidence 0.23 Published 1981 Journal Neurosci. Lett. Section Title Doc Link 7219880 Disease Relevance 0 Pain Relevance 0.58
The structurally related Met-enkephalin and the functionally related GHRH, as well as LHRH and somatostatin-14 did not bind to these MC receptors.
GHRH Neg (not) Binding (bind) of associated with somatostatin and enkephalin
10) Confidence 0.17 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574823 Disease Relevance 0.15 Pain Relevance 0.35
Morphine alters the levels of growth hormone receptor mRNA and [125I]growth hormone binding in human IM-9 lymphoblasts via a naloxone-reversible mechanism.
growth hormone Binding (binding) of in IM-9 associated with narcan and morphine
11) Confidence 0.13 Published 1997 Journal Mol. Cell. Endocrinol. Section Title Doc Link 9484910 Disease Relevance 0 Pain Relevance 0.76
The GHRH and PAC1 receptors are very likely to have evolved as the result of gene duplication, as they are adjacent in the genome and there is evidence for a single precursor protein encoding the ligands GHRH and PACAP in lower vertebrates.


GHRH Binding (ligands) of
12) Confidence 0.12 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0.05 Pain Relevance 0
The mutation abolishes the ability of the receptor to bind GHRH.
GHRH Binding (bind) of
13) Confidence 0.12 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0.27 Pain Relevance 0.23
Blood was sampled at intervals for serum prolactin, growth hormone (GH), and cortisol.
growth hormone Binding (intervals) of in Blood
14) Confidence 0.11 Published 1987 Journal Psychiatry Res Section Abstract Doc Link 2829259 Disease Relevance 0.09 Pain Relevance 0.51
Immunohistochemical analysis indicated positive reactivity for adrenocorticotropic hormone (ACTH) and growth hormone (GH), and in situ hybridization indicated the expression of proopiomelanocortin (POMC) and GH mRNA.
growth hormone Binding (reactivity) of
15) Confidence 0.08 Published 2001 Journal Acta Neuropathol. Section Abstract Doc Link 11699555 Disease Relevance 0.33 Pain Relevance 0.15
Somatostatin receptors in human growth hormone and prolactin-secreting pituitary adenomas.

[125I-Tyr]Somatostatin [( 125I-Tyr]SRIH) binding was found in 11 GH-secreting pituitary adenomas [Kd = 0.46 +/- 0.15 (+/- SE) nM; maximum binding, 165 +/- 35 fmol/mg protein).

growth hormone Binding (binding) of in pituitary associated with pituitary cancer and somatostatin
16) Confidence 0.08 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2860120 Disease Relevance 0.62 Pain Relevance 0.36
the precise epitope of human growth hormone (hGH) recognized by
growth hormone Binding (recognized) of
17) Confidence 0.05 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.09 Pain Relevance 0
Mature IGF-1 is produced systemically by the interaction of growth hormone (GH) with the liver.
growth hormone Binding (interaction) of in liver
18) Confidence 0.04 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.22 Pain Relevance 0.08
Group A7 is also composed of receptors for peptide ligands: neuromedin, neurotensin, motilin, endothelin, bombesin and the releasing hormones for growth hormone and thyrotropin.
growth hormone Binding (ligands) of
19) Confidence 0.04 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.27
Further, the endocrine and immune systems closely interact (reviewed in [12]), with ACTH, cortisol, prolactin (PRL) and growth hormone (hGH) being most often implicated in the regulation of the immune system.
growth hormone Binding (interact) of in immune system
20) Confidence 0.03 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1501038 Disease Relevance 1.03 Pain Relevance 0.53

General Comments

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