INT199009

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.81
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
leukocyte 2
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 96 91.44 High High
ischemia 30 81.92 Quite High
cytokine 28 81.68 Quite High
Inflammatory mediators 8 69.76 Quite High
tolerance 1 65.52 Quite High
chemokine 7 65.04 Quite High
Sciatic nerve 17 53.12 Quite High
methotrexate 50 52.28 Quite High
Inflammatory response 4 30.80 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 70 99.48 Very High Very High Very High
Stress 9 98.56 Very High Very High Very High
Inflammatory Bowel Disease 5 98.36 Very High Very High Very High
Adhesions 22 97.08 Very High Very High Very High
INFLAMMATION 100 91.44 High High
Cirrhosis 4 89.00 High High
Cv Unclassified Under Development 30 81.92 Quite High
Injury 45 80.68 Quite High
Urological Neuroanatomy 8 80.08 Quite High
Pressure And Volume Under Development 19 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, in HYPO group after RM, the mRNA expression of VCAM-1 and ICAM-1 decreased, probably reflecting reduced shear stress.
Negative_regulation (decreased) of Transcription (expression) of ICAM-1 associated with stress and pressure volume 2 under development
1) Confidence 0.38 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.21 Pain Relevance 0.16
Our data showed that the mRNA expression of ICAM-1 was significantly suppressed by curcumin in vitro and in vivo (Fig. 3B and C).
Negative_regulation (suppressed) of Transcription (expression) of ICAM
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 1.31 Pain Relevance 0.53
A reduced TNF-alpha and ICAM-1 mRNA expression seen after IP may account for the inhibitory effects of IP on leukocyte adhesion and ameloriated microcirculatory disturbance after IR in vivo [23-26].
Negative_regulation (reduced) of Transcription (expression) of ICAM-1 in leukocyte associated with adhesions
3) Confidence 0.31 Published 2006 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1636295 Disease Relevance 0.59 Pain Relevance 0.10
After up to 24 hours in culture, protein and mRNA expression of ICAM-1 was monitored using ELISA and real-time PCR, respectively.
Negative_regulation (monitored) of Transcription (expression) of ICAM-1
4) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.51 Pain Relevance 0.11
Relative mRNA expression of ICAM-1, MCP-1, IL-6, and P-selectin was determined using predeveloped assays for real-time PCR (Applied Biosystems, Foster City, CA).
Spec (determined) Negative_regulation (determined) of Spec (determined) Transcription (expression) of ICAM-1
5) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.18 Pain Relevance 0.06

General Comments

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