INT199011

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 19
Disease Relevance 6.03
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lat) plasma membrane (Lat) intracellular (Lat)
Anatomy Link Frequency
platelet 2
SH2 1
mature T cells 1
a band 1
T-cell 1
Lat (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 57 95.52 Very High Very High Very High
Dopamine 19 81.28 Quite High
Codeine 109 65.76 Quite High
Inflammation 27 55.60 Quite High
Inflammatory response 13 51.52 Quite High
cytokine 38 48.44 Quite Low
tolerance 14 20.56 Low Low
adenocard 24 5.00 Very Low Very Low Very Low
ketamine 18 5.00 Very Low Very Low Very Low
Morphine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 407 100.00 Very High Very High Very High
Cold Sores 801 99.72 Very High Very High Very High
Thrombosis 8 77.28 Quite High
Hemorrhage 8 76.00 Quite High
INFLAMMATION 41 55.60 Quite High
Pressure And Volume Under Development 4 50.16 Quite High
Adhesions 16 38.40 Quite Low
Infection 103 32.80 Quite Low
Bacterial Infection 2 21.80 Low Low
Shock 9 12.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differing dependency on LAT and SLP-76 in the GPVI and CLEC-2 signaling cascades could reflect either the presence of a LAT-like molecule in platelets or the presence of a LAT-independent pathway of recruitment of SLP-76 to the membrane.
LAT-independent Binding (recruitment) of in platelets
1) Confidence 0.32 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0.04
Indeed, it may be that the evolution of a role for Gads in mediating the interaction between LAT and SLP-76 has occurred because of its role in facilitating weak signaling by the pre-TCR to ensure an optimal number of mature T cells in the circulation rather than to facilitate TCR or platelet activation at higher agonist concentrations.
LAT Binding (interaction) of in mature T cells associated with agonist
2) Confidence 0.32 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.13 Pain Relevance 0.05
The relatively minor role of Gads in mediating platelet activation by CRP and rhodocytin raises the issue of whether there is a Gads-related protein that supports platelet activation downstream of GPVI and CLEC-2 through binding to LAT.
LAT Binding (binding) of in platelet
3) Confidence 0.32 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
In comparison to LAT and SLP-76, Gads has a relatively minor role in recruiting SLP-76 to LAT and activation of PLC?
LAT Binding (comparison) of
4) Confidence 0.32 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.15 Pain Relevance 0.03
Tyrosine phosphorylated bands of 38 and 76 kDa, which co-migrate with LAT and SLP-76, respectively, were observed to immunoprecipitate with Gads, along with a band of 45 kDa that was detected after 90 s, and which co-migrates with a band that has previously been identified as Gads [17].
LAT Binding (migrate) of in a band
5) Confidence 0.32 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
The strong binding of Grb2 to LAT is explained by the presence of three sites for association of Grb2 with LAT at phosphotyrosines Y171, Y191, and Y226 [28,32,33], compared with a single site for Gads at phosphotyrosine Y191, and to a lesser extent Y171 [28,32,33].
LAT Binding (binding) of
6) Confidence 0.32 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
can be recruited to LAT through a direct interaction between LAT Y132 and its N-terminal SH2 domain [37–39].
LAT Binding (recruited) of in SH2
7) Confidence 0.32 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.10 Pain Relevance 0.05
Beginning as early as 0.5 h post-TCIE, we found a decrease in the H3K4me2 enrichment associated with the LAT 5?
LAT 5 Binding (associated) of
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.67 Pain Relevance 0
Gads binds constitutively to SLP-76 and associates with LAT upon T-cell receptor (TCR) activation forming a LAT signalosome that is critical for activation of PLC?
LAT Binding (signalosome) of in T-cell
9) Confidence 0.28 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
We further extended our analyses to determine if the decrease in H3K4me2 enrichment associated with the LAT 5?
LAT 5 Binding (associated) of
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.24 Pain Relevance 0
We found a similar pattern of H3K4me2 enrichment in the KOS strain, where the LAT5?
LAT5 Binding (found) of associated with sprains and strains
11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.04 Pain Relevance 0
Our data shows that epigenetic changes to chromatin associated with the LAT 5?
LAT 5 Binding (associated) of
12) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.21 Pain Relevance 0
This finding, coupled with the unchanging abundance of LAT RNA indicate that changes in histone markers on the LAT and the IE regions of HSV-1 may be a crucial factor in in vivo reactivation.
LAT RNA Neg (unchanging) Binding (abundance) of associated with cold sores
13) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.58 Pain Relevance 0
Our data shows that the enrichment of euchromatin associated with the LAT 5?
LAT 5 Binding (associated) of
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.49 Pain Relevance 0
We found that the LAT 5?
LAT 5 Binding (found) of
15) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.00 Pain Relevance 0
Our results suggest that the LAT 5?
LAT 5 Binding (suggest) of
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.29 Pain Relevance 0
In contrast, when the same experimental protocol was applied to rabbits latent with HSV-1 strain KOS, with the goal being to determine whether we could observe a difference in the patterns of enrichment of H3K4me2 associated with the LAT region of KOS following TCIE of latently infected rabbits, we found no significant change (either increase or decrease) in the overall enrichment of H3K4me2 for the LAT 5?
LAT Binding (associated) of associated with cold sores and sprains and strains
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.94 Pain Relevance 0
Upon ligand binding, the TCR is recruited to the lipid raft where it associates with kinase signaling components such as Lck and Lat.
Lat Binding (associates) of
18) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.16 Pain Relevance 0.05
The potential elimination of non-specific interactions between an aptamer and the linker protein by the direct coupling small molecule-aptamer binding assay was demonstrated on a previously characterized RNA aptamer to a different small molecule target.
linker protein Binding (interactions) of
19) Confidence 0.00 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.20

General Comments

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