INT19904

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cux1) nucleus (Cux1) protein binding, bridging (Cux1)
DNA binding (Cux1) cytoplasm (Cux1)
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 99.84 Very High Very High Very High
antidepressant 83 99.54 Very High Very High Very High
depression 19 96.52 Very High Very High Very High
Morphine 3 89.36 High High
opiate 3 87.20 High High
antagonist 1 79.08 Quite High
monoamine 13 28.96 Quite Low
fluoxetine 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
sSRI 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 19 96.52 Very High Very High Very High
Suicidal Behaviour 1 89.28 High High
Neurodegenerative Disease 2 81.64 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A higher dose of CDP did not reveal a release of endogenous opioids, and a higher dose of NLX did not antagonize CDP.
Localization (release) of CDP associated with endogenous opioid
1) Confidence 0.65 Published 1990 Journal Behav. Neurosci. Section Abstract Doc Link 2107826 Disease Relevance 0 Pain Relevance 0.81
Thus, it is conceivable that an early action of antidepressant agents to enhance the mobilization of CDP-DG could lead to coordinate effects on multiple signaling systems, which might then explain the various molecular, structural, and functional effects of the drugs.
Localization (mobilization) of CDP associated with antidepressant
2) Confidence 0.57 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.41 Pain Relevance 0.29

General Comments

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