INT199062

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
monocytes 1
Ncf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 31 86.24 High High
cytokine 24 68.20 Quite High
Inflammatory mediators 4 45.12 Quite Low
Inflammatory response 11 23.20 Low Low
Inflammatory stimuli 5 12.92 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 61 89.96 High High
INFLAMMATION 54 86.24 High High
Stress 6 50.00 Quite Low
Neutrophil Disorders 3 5.84 Low Low
Death 10 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 7 5.00 Very Low Very Low Very Low
Amyloid Plaque 7 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?
Transcription (transcripts) of p47phox in monocytes
1) Confidence 0.19 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03
Similarly, mRNA levels of NADPH oxidase cytosolic subunit p67phox and membrane subunit gp91phox were significantly elevated at 24 h after LPS injection in both genotypes compared with vehicle-injected controls (Fig. 5B and 5C).
Transcription (levels) of NADPH oxidase cytosolic subunit
2) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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