INT199064

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.27
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ncf2) nucleolus (Ncf2) cytoplasm (Ncf2)
Anatomy Link Frequency
be cell 1
Ncf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 96.92 Very High Very High Very High
Inflammatory stimuli 13 94.76 High High
Inflammation 71 71.76 Quite High
COX-2 inhibitor 4 69.36 Quite High
cytokine 44 61.04 Quite High
Inflammatory response 31 47.12 Quite Low
Inflammatory mediators 8 36.20 Quite Low
cINOD 34 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
Central nervous system 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 130 94.44 High High
Stress 18 50.00 Quite Low
Disease 293 30.92 Quite Low
Amyloid Plaque 35 12.28 Low Low
Death 42 5.00 Very Low Very Low Very Low
Cognitive Disorder 32 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 30 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 28 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 23 5.00 Very Low Very Low Very Low
Neutrophil Disorders 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein levels of p67phox (Fig. 7C and 7D) and phosphorylated STAT3 after LPS (Fig. 7E and 7F) were also higher in the celecoxib-treated mice compared to untreated mice.


Phosphorylation (phosphorylated) of p67phox
1) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.05 Pain Relevance 0.09
These cytoplasmic signaling events stimulate the phosphorylation of p47phox and p67phox and the GDP/GTP exchange on Rac.
Phosphorylation (phosphorylation) of p67phox
2) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.17 Pain Relevance 0.08
The diversity of kinases implicated in the phosphorylation of p47phox and p67phox suggests that the intracellular signaling pathways responsible for this phosphorylation event are complex and may be cell type and stimulus specific.
Phosphorylation (phosphorylation) of p67phox in be cell
3) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0 Pain Relevance 0.05
Analysis of p47phox and p67phox phosphorylation has been investigated with the use of specific protein kinase inhibitors revealing that protein kinase C (PKC) [37-39], p21-activated kinase-1 (PAK1) [40], mitogen-activated protein kinase (MAPK) [41], Akt [42], and phosphatidylinositol-3 kinase (PI3K) [43] phophorylate p47phox or p67phox.
Phosphorylation (phosphorylation) of p67phox associated with kinase c
4) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0 Pain Relevance 0.05
Analysis of p47phox and p67phox phosphorylation has been investigated with the use of specific protein kinase inhibitors revealing that protein kinase C (PKC) [37-39], p21-activated kinase-1 (PAK1) [40], mitogen-activated protein kinase (MAPK) [41], Akt [42], and phosphatidylinositol-3 kinase (PI3K) [43] phophorylate p47phox or p67phox.
Phosphorylation (phophorylate) of p67phox associated with kinase c
5) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0 Pain Relevance 0.05
Cytosolic p47phox and p67phox are often found as a complex and both require phosphorylation prior to their translocation to the membrane [34,36].
Phosphorylation (phosphorylation) of p67phox
6) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07

General Comments

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