INT199071

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.52
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb)
Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)
Anatomy Link Frequency
retina 2
neurons 2
brain 2
central nervous system 2
Cybb (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 8 98.60 Very High Very High Very High
Inflammation 37 94.76 High High
cytokine 36 92.56 High High
Nerve growth factor 1 92.44 High High
ischemia 23 90.44 High High
chemokine 9 67.16 Quite High
GABAergic 27 60.92 Quite High
Inflammatory response 8 59.56 Quite High
imagery 19 48.04 Quite Low
Hippocampus 41 38.72 Quite Low
Disease Link Frequency Relevance Heat
Infection 69 96.40 Very High Very High Very High
Apoptosis 129 95.08 Very High Very High Very High
INFLAMMATION 49 94.76 High High
Cancer 9 93.20 High High
Stress 9 92.76 High High
Mycobacterial Infection 141 91.16 High High
Cv Unclassified Under Development 8 90.44 High High
Schizophrenia 6 89.60 High High
Injury 18 80.96 Quite High
Death 23 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreased expression of Nox2 we observed in old IL-6-/- mice compared to wild-type mice was accompanied by a significant reduction in nuclear NF?
Negative_regulation (decreased) of Gene_expression (expression) of Nox2
1) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.28 Pain Relevance 0.12
Increased Nox2 protein expression in brain of aged animals is attenuated in IL-6-/- mice
Negative_regulation (attenuated) of Gene_expression (expression) of Nox2 protein in brain
2) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.33 Pain Relevance 0.06
More importantly, direct application of IL-6 to cultured neurons resulted in a significant increase in Nox-2 expression and superoxide production which was fully blocked by the NF?
Negative_regulation (blocked) of Gene_expression (expression) of Nox-2 in neurons
3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.16 Pain Relevance 0.12
Our analysis of IR-challenged retinas revealed that the gene expression of Nos2 and Cybb was suppressed in the retina of Tlr4 KO animals relative to WT controls.
Negative_regulation (suppressed) of Gene_expression (expression) of Cybb in retina
4) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.83 Pain Relevance 0.30
In the central nervous system, Noh and Koh (2000) were able to demonstrate increased NADPH oxidase-derived (NOX2) ROS production in cortical cultures in response to zinc exposure [72].
Negative_regulation (derived) of Gene_expression (production) of NOX2 in central nervous system associated with central nervous system
5) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.35 Pain Relevance 0.14
In conclusion, these results serendipitously reveal a novel connection between NOX2 activity, phagosomal ROS, and TNF-?
Negative_regulation (connection) of Gene_expression (activity) of NOX2
6) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2858756 Disease Relevance 1.57 Pain Relevance 0

General Comments

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