INT199073

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.64
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
plasma 1
monocytes 1
microglia 1
Ncf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 86 85.84 High High
Enkephalin 1 77.40 Quite High
cytokine 28 68.88 Quite High
Inflammatory response 13 67.20 Quite High
Inflammatory mediators 11 50.40 Quite High
addiction 1 17.80 Low Low
Inflammatory stimuli 5 13.60 Low Low
cINOD 11 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 249 98.32 Very High Very High Very High
Obesity 338 97.96 Very High Very High Very High
Disease 92 90.64 High High
INFLAMMATION 119 85.84 High High
Apoptosis 5 82.80 Quite High
Hypertrophy 3 82.36 Quite High
Stress 66 80.24 Quite High
Pathologic Processes 1 77.76 Quite High
Parkinson's Disease 36 71.20 Quite High
Drug Induced Neurotoxicity 37 69.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production and
                               p47phox upregulation in
                       young but not aging ob/ob mice. 
Positive_regulation (upregulation) of p47phox associated with aging and obesity
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 1.21 Pain Relevance 0
As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.
Positive_regulation (followed) of p47phox in plasma
2) Confidence 0.24 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.17
Data from subcellular fractionation and western blot analysis clearly showed an increase in immunoreactivity of p47phox in the membrane of microglia 10 min after LPS treatment (Fig. 6C), and this increase in immunoreactivity was significantly blocked in the presence of FLZ.
Positive_regulation (increase) of p47phox in microglia
3) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.19 Pain Relevance 0
Our observation of elevated
                   O2- production and upregulated
                       p47phox subunit of NADPH
               oxidase in both aging and obese groups (without interaction between the two)
               suggests a likely role of NADPH oxidase-dependent
                   O2? 
Positive_regulation (upregulated) of p47phox associated with aging and obesity
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.11 Pain Relevance 0
Similarly, mRNA levels of NADPH oxidase cytosolic subunit p67phox and membrane subunit gp91phox were significantly elevated at 24 h after LPS injection in both genotypes compared with vehicle-injected controls (Fig. 5B and 5C).
Positive_regulation (elevated) of NADPH oxidase cytosolic subunit
5) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.14 Pain Relevance 0.07
Several studies have indicated that induction or up-regulation of p47phox and p67phox protein may occur within a short time frame as short as 15 min [20], [31], [32].
Positive_regulation (induction) of p47phox
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.52 Pain Relevance 0.04
-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?
Positive_regulation (increase) of p47phox in monocytes
7) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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