INT199073

Context Info Confidence 0.27 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 3.64 Pain Relevance 0.31

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1) plasma membrane (Ncf1) cytoplasm (Ncf1)

Anatomy Link Frequency plasma 1 monocytes 1 microglia 1 Ncf1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 86 85.84 Enkephalin 1 77.40 cytokine 28 68.88 Inflammatory response 13 67.20 Inflammatory mediators 11 50.40 addiction 1 17.80 Inflammatory stimuli 5 13.60 cINOD 11 5.00 chemokine 11 5.00 Central nervous system 10 5.00

Disease Link Frequency Relevance Heat Aging 249 98.32 Obesity 338 97.96 Disease 92 90.64 INFLAMMATION 119 85.84 Apoptosis 5 82.80 Hypertrophy 3 82.36 Stress 66 80.24 Pathologic Processes 1 77.76 Parkinson's Disease 36 71.20 Drug Induced Neurotoxicity 37 69.92

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production and p47phox upregulation in young but not aging ob/ob mice.

Positive_regulation (upregulation) of p47phox associated with aging and obesity

1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 1.21 Pain Relevance 0

As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.

Positive_regulation (followed) of p47phox in plasma

2) Confidence 0.24 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.17

Data from subcellular fractionation and western blot analysis clearly showed an increase in immunoreactivity of p47phox in the membrane of microglia 10 min after LPS treatment (Fig. 6C), and this increase in immunoreactivity was significantly blocked in the presence of FLZ.

Positive_regulation (increase) of p47phox in microglia

3) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.19 Pain Relevance 0

Our observation of elevated O2- production and upregulated p47phox subunit of NADPH oxidase in both aging and obese groups (without interaction between the two) suggests a likely role of NADPH oxidase-dependent O2?

Positive_regulation (upregulated) of p47phox associated with aging and obesity

4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.11 Pain Relevance 0

Similarly, mRNA levels of NADPH oxidase cytosolic subunit p67phox and membrane subunit gp91phox were significantly elevated at 24 h after LPS injection in both genotypes compared with vehicle-injected controls (Fig. 5B and 5C).

Positive_regulation (elevated) of NADPH oxidase cytosolic subunit

5) Confidence 0.10 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.14 Pain Relevance 0.07

Several studies have indicated that induction or up-regulation of p47phox and p67phox protein may occur within a short time frame as short as 15 min [20], [31], [32].

Positive_regulation (induction) of p47phox

6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.52 Pain Relevance 0.04

-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?

Positive_regulation (increase) of p47phox in monocytes

7) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03

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