INT199073
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
production and
p47phox upregulation in young but not aging ob/ob mice. | |||||||||||||||
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As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex. | |||||||||||||||
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Data from subcellular fractionation and western blot analysis clearly showed an increase in immunoreactivity of p47phox in the membrane of microglia 10 min after LPS treatment (Fig. 6C), and this increase in immunoreactivity was significantly blocked in the presence of FLZ. | |||||||||||||||
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Our observation of elevated
O2- production and upregulated p47phox subunit of NADPH oxidase in both aging and obese groups (without interaction between the two) suggests a likely role of NADPH oxidase-dependent O2? | |||||||||||||||
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Similarly, mRNA levels of NADPH oxidase cytosolic subunit p67phox and membrane subunit gp91phox were significantly elevated at 24 h after LPS injection in both genotypes compared with vehicle-injected controls (Fig. 5B and 5C). | |||||||||||||||
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Several studies have indicated that induction or up-regulation of p47phox and p67phox protein may occur within a short time frame as short as 15 min [20], [31], [32]. | |||||||||||||||
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-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF? | |||||||||||||||
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General Comments
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