INT199076

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.12
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Syk) cytoplasm (Syk)
Syk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 35 89.84 High High
Inflammatory stimuli 2 53.48 Quite High
Inflammation 34 34.44 Quite Low
Kinase C 1 5.68 Low Low
Inflammatory response 17 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 69.96 Quite High
INFLAMMATION 61 53.12 Quite High
Parasitemia 12 48.96 Quite Low
Disease 76 45.76 Quite Low
Plasmodium Infection 51 39.12 Quite Low
Apoptosis 6 6.72 Low Low
Infection 27 5.00 Very Low Very Low Very Low
Fever 18 5.00 Very Low Very Low Very Low
Death 11 5.00 Very Low Very Low Very Low
Rupture 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, Hz-induced Syk activation is not affected by the absence of the MyD88 adaptor protein (Fig.
Positive_regulation (activation) of Syk
1) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
The Lyn/Syk pathway appears to be uniquely activated in the innate response to Hz crystals, as opposed to other NLRP3-activating crystals such as MSU.
Positive_regulation (activated) of Syk
2) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.07 Pain Relevance 0
Altogether, these results reveal that Lyn/Syk activation following Hz exposure initiates the PI3K and ERK signaling pathways and these pathways appear to regulate the production of mature IL-1?.
Positive_regulation (activation) of Syk
3) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
A novel variation of this signaling pathway has been described in which the C-type lectin family receptors, CLEC-2, Dectin-1, and CLEC-9A, signal through sequential activation of Src and Syk family tyrosine kinases downstream of a single YxxL sequence [1–3].
Positive_regulation (activation) of Syk
4) Confidence 0.27 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
engagement of this receptor complex leads to the initiation of complex signaling events leading to protein tyrosine phosphorylation and activation of the src-family kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52].
Positive_regulation (activation) of Syk
5) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07

General Comments

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