INT199077

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.43
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
monocytes 1
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 14 89.92 High High
cytokine 117 86.40 High High
Inflammation 162 65.96 Quite High
Inflammatory stimuli 7 6.20 Low Low
metalloproteinase 105 5.00 Very Low Very Low Very Low
COX-2 inhibitor 29 5.00 Very Low Very Low Very Low
chemokine 29 5.00 Very Low Very Low Very Low
Inflammatory response 21 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
GABAergic 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 238 100.00 Very High Very High Very High
Infection 108 100.00 Very High Very High Very High
Hypothermia 28 93.92 High High
Disease 90 83.24 Quite High
Cancer 97 82.12 Quite High
Stress 21 71.44 Quite High
Adhesions 54 66.20 Quite High
INFLAMMATION 198 65.96 Quite High
Apoptosis 26 64.24 Quite High
Metastasis 7 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This data suggested that the factors released during KSHV infection up-regulated RhoA-GTPase in the adhering cells.
Localization (released) of GTPase associated with herpes simplex virus and infection
1) Confidence 0.73 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.74 Pain Relevance 0
Recently, we have demonstrated that the Rac GTPase is also activated and subsequently translocated from the cytosol to the membrane of THP-1 monocytes in a fA?
Localization (translocated) of GTPase in monocytes
2) Confidence 0.13 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.08 Pain Relevance 0.03
Specifically, dynamin GTPase domain mutations that inhibit endocytosis when expressed in COS-7 cells have a reticular type of localization as opposed to the more diffuse cytoplasmic localization of wildtype dynamin [34].
Localization (localization) of GTPase
3) Confidence 0.11 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0 Pain Relevance 0
Specifically, dynamin GTPase domain mutations that inhibit endocytosis when expressed in COS-7 cells have a reticular type of localization as opposed to the more diffuse cytoplasmic localization of wildtype dynamin [34].
Localization (localization) of GTPase
4) Confidence 0.11 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0 Pain Relevance 0
In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?
Localization (related) of GTPase
5) Confidence 0.09 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.42 Pain Relevance 0.18
In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?
Localization (related) of GTPase
6) Confidence 0.09 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.41 Pain Relevance 0.18
In contrast, Guanine dissociation inhibitors (GDIs), which inhibit the release of GDP and GTPase activating proteins (GAPs), increases the rate at which Rho hydrolyzes GTP keeps the Rho inactivated.
Localization (release) of GTPase
7) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.66 Pain Relevance 0
This GTPase-induced STAT3 translocation was blocked to varying degrees by neutralizing IL-6 receptor antibodies, supporting a role for autocrine IL-6 in Rho family-induced STAT3 activation.
Localization (translocation) of GTPase
8) Confidence 0.01 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.12 Pain Relevance 0.04

General Comments

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