INT199078

Context Info Confidence 0.59 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 3.83 Pain Relevance 0.41

mitochondrion (Nox4) oxidoreductase activity (Nox4) cell morphogenesis (Nox4) endoplasmic reticulum (Nox4) plasma membrane (Nox4)

Anatomy Link Frequency brain 2 Nox4 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 31 96.16 diabetic neuropathy 6 95.12 ischemia 2 89.68 Nerve growth factor 1 86.56 Central nervous system 2 77.28 GABAergic 9 50.00 Inflammatory response 11 13.88 chemokine 23 5.00 cytokine 14 5.00 Hippocampus 14 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 464 100.00 Hypertrophy 3 98.88 Targeted Disruption 4 97.32 INFLAMMATION 46 96.16 Diabetic Neuropathy 6 95.12 Cv Unclassified Under Development 2 89.68 Death 17 89.00 Drug Induced Neurotoxicity 5 85.56 Genetic Predisposition To Disease 12 67.92 Cognitive Disorder 41 50.00

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Previous studies have reported that Nox2 and Nox4 are the only NADPH oxidase isoforms expressed in the adult mouse nervous system[28], a finding we confirmed by RT-PCR in brain of old mice as well (Dugan and Zheng, unpublished).

Gene_expression (expressed) of Nox4 in brain

1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0

NOX4 (NADPH oxidase 4) is the major source of ROS in the kidneys during early stages of diabetes, and NOX4-derived ROS mediates renal hypertrophy and increased fibronectin expression [94].

Gene_expression (source) of NOX4 associated with hypertrophy and diabetes mellitus

2) Confidence 0.51 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.14 Pain Relevance 0.10

NOX4 (NADPH oxidase 4) is the major source of ROS in the kidneys during early stages of diabetes, and NOX4-derived ROS mediates renal hypertrophy and increased fibronectin expression [94].

Gene_expression (source) of NADPH oxidase 4 associated with hypertrophy and diabetes mellitus

3) Confidence 0.51 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.14 Pain Relevance 0.10

NOX4 (NADPH oxidase 4) is the major source of ROS in the kidneys during early stages of diabetes, and NOX4-derived ROS mediates renal hypertrophy and increased fibronectin expression [94].

Gene_expression (source) of NOX4 associated with hypertrophy and diabetes mellitus

4) Confidence 0.51 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.14 Pain Relevance 0.09

It has also recently been appreciated that the NOX4 subunit is present in mouse brain in cortex, in hippocampal neurons, and in Purkinje cells [73].

Gene_expression (present) of NOX4 subunit in brain

5) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.41 Pain Relevance 0.13

General Comments

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