INT199078

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.83
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nox4) oxidoreductase activity (Nox4) cell morphogenesis (Nox4)
endoplasmic reticulum (Nox4) plasma membrane (Nox4)
Anatomy Link Frequency
brain 2
Nox4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 31 96.16 Very High Very High Very High
diabetic neuropathy 6 95.12 Very High Very High Very High
ischemia 2 89.68 High High
Nerve growth factor 1 86.56 High High
Central nervous system 2 77.28 Quite High
GABAergic 9 50.00 Quite Low
Inflammatory response 11 13.88 Low Low
chemokine 23 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 464 100.00 Very High Very High Very High
Hypertrophy 3 98.88 Very High Very High Very High
Targeted Disruption 4 97.32 Very High Very High Very High
INFLAMMATION 46 96.16 Very High Very High Very High
Diabetic Neuropathy 6 95.12 Very High Very High Very High
Cv Unclassified Under Development 2 89.68 High High
Death 17 89.00 High High
Drug Induced Neurotoxicity 5 85.56 High High
Genetic Predisposition To Disease 12 67.92 Quite High
Cognitive Disorder 41 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have reported that Nox2 and Nox4 are the only NADPH oxidase isoforms expressed in the adult mouse nervous system[28], a finding we confirmed by RT-PCR in brain of old mice as well (Dugan and Zheng, unpublished).
Gene_expression (expressed) of Nox4 in brain
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
NOX4 (NADPH oxidase 4) is the major source of ROS in the kidneys during early stages of diabetes, and NOX4-derived ROS mediates renal hypertrophy and increased fibronectin expression [94].
Gene_expression (source) of NOX4 associated with hypertrophy and diabetes mellitus
2) Confidence 0.51 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.14 Pain Relevance 0.10
NOX4 (NADPH oxidase 4) is the major source of ROS in the kidneys during early stages of diabetes, and NOX4-derived ROS mediates renal hypertrophy and increased fibronectin expression [94].
Gene_expression (source) of NADPH oxidase 4 associated with hypertrophy and diabetes mellitus
3) Confidence 0.51 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.14 Pain Relevance 0.10
NOX4 (NADPH oxidase 4) is the major source of ROS in the kidneys during early stages of diabetes, and NOX4-derived ROS mediates renal hypertrophy and increased fibronectin expression [94].
Gene_expression (source) of NOX4 associated with hypertrophy and diabetes mellitus
4) Confidence 0.51 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.14 Pain Relevance 0.09
It has also recently been appreciated that the NOX4 subunit is present in mouse brain in cortex, in hippocampal neurons, and in Purkinje cells [73].
Gene_expression (present) of NOX4 subunit in brain
5) Confidence 0.05 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.41 Pain Relevance 0.13

General Comments

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