INT199079

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.17
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ncf2) nucleolus (Ncf2) cytoplasm (Ncf2)
Anatomy Link Frequency
plasma 1
monocytes 1
Ncf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 42 79.44 Quite High
Enkephalin 1 76.44 Quite High
cytokine 6 74.52 Quite High
Inflammatory response 7 66.24 Quite High
addiction 1 24.96 Low Low
Inflammatory mediators 8 22.80 Low Low
Inflammatory stimuli 2 19.24 Low Low
cINOD 6 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 75 96.28 Very High Very High Very High
Apoptosis 2 89.96 High High
Hypertrophy 1 89.52 High High
Pathologic Processes 1 84.92 Quite High
INFLAMMATION 60 79.44 Quite High
Death 21 66.64 Quite High
Stress 29 64.08 Quite High
Drug Induced Neurotoxicity 27 63.12 Quite High
Infection 12 56.84 Quite High
Bacillus Anthracis Infection 28 55.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-treated cultured monocytes and primary microglia [28], there is a translocation of both the p47phox and p67phox subunits from the cytosol to the membrane.
Localization (translocation) of p67phox in monocytes
1) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.10 Pain Relevance 0.04
As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.
Localization (translocation) of p67phox in plasma
2) Confidence 0.17 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.17
Apocynin is known to inhibit p47phox and p67phox translocation and superoxide formation through blockade of sulfhydryl groups thus interrupting the NADPH oxidase enzyme assembly [30].
Localization (translocation) of p67phox
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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