INT199080

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.74
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Vav1)
Anatomy Link Frequency
microglia 1
Vav1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 56.24 Quite High
cytokine 5 31.60 Quite Low
Inflammation 12 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 94.24 High High
Glaucoma 108 80.52 Quite High
Targeted Disruption 7 79.28 Quite High
Neutrophil Disorders 3 78.00 Quite High
Ocular Hypertension 114 76.68 Quite High
Disease 62 74.64 Quite High
Optic Disorders 4 67.92 Quite High
Stress 3 50.00 Quite Low
Hydrophthalmos 10 8.24 Low Low
INFLAMMATION 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three mammalian Vav proteins, Vav1, Vav2, and Vav3, share a Dbl homology domain for their enzymatic activity as GEFs and contain a common structural array characteristic of proteins involved in signal transduction.
Localization (share) of Vav1
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.73 Pain Relevance 0
The three mammalian Vav proteins, Vav1, Vav2, and Vav3, share a Dbl homology domain for their enzymatic activity as GEFs and contain a common structural array characteristic of proteins involved in signal transduction.
Localization (share) of Vav
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.73 Pain Relevance 0
Importantly, genetic deletion of Vav from primary microglia resulted in severe attenuation of ROS production following fA?
Localization (deletion) of Vav in microglia
3) Confidence 0.27 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.28 Pain Relevance 0.03

General Comments

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