INT199082

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.25
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
plasma 4
heart 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 4 92.52 High High
alcohol 9 70.80 Quite High
COX-2 inhibitor 6 47.32 Quite Low
Kinase C 3 44.72 Quite Low
fibrosis 1 32.64 Quite Low
Inflammation 24 18.44 Low Low
cytokine 6 7.52 Low Low
cINOD 13 5.00 Very Low Very Low Very Low
tolerance 11 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 18 95.40 Very High Very High Very High
INFLAMMATION 36 92.16 High High
Stress 33 87.52 High High
Tuberous Sclerosis 1 85.44 High High
Apoptosis 17 82.60 Quite High
Cancer 62 80.88 Quite High
Starvation 6 78.12 Quite High
Coronary Heart Disease 4 76.40 Quite High
Targeted Disruption 19 70.04 Quite High
Alcohol Addiction 3 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The isoprenoid geranylgeranylpyrophosphate activates a group of Rho, Rac and cdc42 proteins (Adamson et al. 1992).
Positive_regulation (activates) of Rac Binding (group) of
1) Confidence 0.17 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.32 Pain Relevance 0
Rac is then able to translocate to the plasma membrane, where its prenyl group inserts into the membrane, tethering Rac to its inner face and facilitating Rac's interaction with p67phox [45].
Positive_regulation (facilitating) of Rac Binding (interaction) of in plasma
2) Confidence 0.17 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.05
In this study, overexpression of ALDH2 was associated with a suppression of phosphatase activity which leads to enhanced Akt and AMP-activated protein kinase activities and regulation of their downstream targets Foxo3 transcription factor and caspase-3.87,88 Thus, ALDH2 appears critical in protecting the heart from aldehyde toxicity and is able to elicit signalling events that can protect against myocardial damages caused by acute ethanol toxicity.
Positive_regulation (enhanced) of Akt Binding (targets) of in heart associated with toxicity
3) Confidence 0.15 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.67 Pain Relevance 0.06
Activated PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the plasma membrane, which increases the membrane recruitment of Akt/PKB and its activator PDK1, leading to the activation of Akt.
Positive_regulation (increases) of Akt Binding (recruitment) of in plasma
4) Confidence 0.09 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.16 Pain Relevance 0

General Comments

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