INT199084

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 16.94
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Cd36) transport (Cd36) mitochondrion (Cd36)
cell adhesion (Cd36) Golgi apparatus (Cd36) plasma membrane (Cd36)
Anatomy Link Frequency
macrophages 3
monocytes 2
liver 1
fibroblasts 1
peritoneal macrophages 1
Cd36 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 192 100.00 Very High Very High Very High
Inflammation 920 99.70 Very High Very High Very High
tolerance 89 97.32 Very High Very High Very High
Hippocampus 63 92.80 High High
agonist 247 82.36 Quite High
Kinase C 7 82.32 Quite High
Inflammatory mediators 13 79.36 Quite High
Multiple sclerosis 100 72.08 Quite High
cannabis 1 70.48 Quite High
fibrosis 86 70.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1017 99.70 Very High Very High Very High
Targeted Disruption 197 99.52 Very High Very High Very High
Coronary Heart Disease 34 99.00 Very High Very High Very High
Death 98 98.94 Very High Very High Very High
Atherosclerosis 111 98.76 Very High Very High Very High
Obesity 127 98.24 Very High Very High Very High
Necrosis 57 98.24 Very High Very High Very High
Diabetes Mellitus 140 98.20 Very High Very High Very High
Disorder Of Lipid Metabolism 45 98.20 Very High Very High Very High
Cancer 823 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that enhanced expression of CD36 and CPT1 perhaps contributes to the maintenance of normal glucose tolerance despite the absence of GPR40 under basal conditions, but that the absence of such an increase under HFD results in an inability of the mice to sustain normal GSIS.
Gene_expression (expression) of CD36 associated with tolerance and impaired glucose tolerance
1) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.68 Pain Relevance 0.05
GPR40 KO mice on regular diet displayed an approximate five and sevenfold increase in islet CD36 and CPT-1 mRNA expression, respectively, compared with WT islets (Table 1), suggesting an attempt to compensate for the absence of GPR40 by enhancing fatty acid transport and intracellular metabolism.
Gene_expression (expression) of CD36 associated with targeted disruption
2) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.52 Pain Relevance 0.03
Although expression of neither CD36 nor CPT-1 was significantly affected by HFD in WT animals, in KO islets the increase in CD36 and CPT1 gene expression was markedly reduced by HFD.
Gene_expression (expression) of CD36 associated with targeted disruption
3) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.61 Pain Relevance 0.04
Although expression of neither CD36 nor CPT-1 was significantly affected by HFD in WT animals, in KO islets the increase in CD36 and CPT1 gene expression was markedly reduced by HFD.
Gene_expression (expression) of CD36 associated with targeted disruption
4) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2518494 Disease Relevance 0.69 Pain Relevance 0.04
target genes Lpl, PEPCK, CD36, and adiponectin was markedly decreased in adipose tissue from PPAR?
Gene_expression (genes) of CD36 in adipose tissue associated with obesity
5) Confidence 0.44 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.33 Pain Relevance 0.03
target genes (Lpl, PEPCK, CD36 and adiponectin) in gonadal fat isolated from these mice revealed no significant differences in the expression level between vehicle and DPN-treated rodents indicating ligand independency (Figure 4C).
Gene_expression (expression) of CD36 in fat
6) Confidence 0.44 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.06 Pain Relevance 0
Microarrays provide insight into the molecular pathogenesis of the processes in the outbred mice reflecting inflammation, attenuation of this inflammation by counter regulatory processes, neuronal cell death and potential remodeling of synapses with increased expression of C1q, as well as CD36, immunoglobin genes, GFAP, and PD-1L in these transcriptomes.
Gene_expression (expression) of CD36 in neuronal associated with inflammation and death
7) Confidence 0.42 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.13 Pain Relevance 0.29
Further, the increased expression of PD-1 ligand and CD36 raise the provocative questions about whether T. gondii shares mechanisms to down-modulate critical protective immune functions that also allow latency in infections with certain viruses or cause pro-inflammation contributing to neurodegeneration.
Gene_expression (expression) of CD36 associated with inflammation and infection
8) Confidence 0.42 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.26 Pain Relevance 0.12
In addition, there was increased expression of the Suppression of Cytokine Signaling (SOCS), CD36, and PD-1L genes and others including C1q.
Gene_expression (expression) of CD36 associated with cytokine
9) Confidence 0.42 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.45 Pain Relevance 0.13
Flow cytometry analysis of the cultured BM-MC showed expression of CD45, CD11b, CD11c, CD36, and F4/80 (Figure 2A).
Gene_expression (expression) of CD36 in F4/80
10) Confidence 0.40 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.39 Pain Relevance 0.12
For neutralizing antibody experiments the A4.1 anti-TSP-1 monoclonal antibody (Lab Vision, Fremont, CA) (CSVTCG/CD36) or control antibody (IgM) at 50 µg/mouse were administered intraperitoneally daily to PPAR?
Gene_expression (/) of CD36
11) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.79 Pain Relevance 0
Microarrays reflect inflammation and increased expression of CD36 and PD1L, GFAP, ubiquitin ligase, and C1q
Gene_expression (expression) of CD36 associated with inflammation
12) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.38 Pain Relevance 0.05
CD36 is expressed in endothelium (small vessels) and a variety of epithelial and stromal cells.(26) Some of the antiangiogenic functions of TSP1 are directly mediated by the binding of TSP1 with CD36.(27) TSP1 also has important functions in inflammation that are dependent of its binding with CD36.(28)
Gene_expression (expressed) of CD36 in stromal cells associated with inflammation
13) Confidence 0.32 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.17 Pain Relevance 0.09
Vascular endothelium expression of CD36 is sporadic however, with lower levels of expression in larger vessels [196, 228].
Gene_expression (expression) of CD36 in vessels
14) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.73 Pain Relevance 0.04
TSP-1 is a large molecular weight glycoprotein that inhibits the proliferation and migration of ECs by interacting with CD36 expressed on the cell surface; CD36 is a PPAR?
Gene_expression (expressed) of CD36
15) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.17 Pain Relevance 0.03
TREM2 cross-linking antibodies stimulated phosphorylation of ERK in TREM2-transduced BM-MC (Figure 3), but did not modify cell surface expression of MHC class II, CD80, CD86, CD36, CCR7, and CD11c (Figure S1).
Gene_expression (expression) of CD36 in CD86
16) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.61 Pain Relevance 0.22
as preincubation of cells with a CD36 blocking antibody had no effect on fA?
Gene_expression (antibody) of CD36
17) Confidence 0.30 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.13 Pain Relevance 0
Furthermore, expression of the related human scavenger receptor CD36 has been found to be lower on monocytes in TB patients, and reverse to normal levels upon anti-mycobacterial treatment [46].
Gene_expression (expression) of CD36 in monocytes
18) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.44 Pain Relevance 0.04
CD36, a scavenger receptor class B1 [30] was not expressed by pMSC.
Neg (not) Gene_expression (expressed) of CD36
19) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.58 Pain Relevance 0
CD36 was not expressed in pMSC whereas a double population was observed in aMSC.
Neg (not) Gene_expression (expressed) of CD36
20) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.20 Pain Relevance 0

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