INT199089

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.16
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb)
Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)
Anatomy Link Frequency
monocytes 1
microglia 1
Cybb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 64 86.24 High High
Substantia nigra 37 71.04 Quite High
dopaminergic neurodegeneration 5 70.56 Quite High
cytokine 51 68.20 Quite High
Inflammatory mediators 8 65.20 Quite High
midbrain 3 50.88 Quite High
Dopamine 6 45.12 Quite Low
Inflammatory response 19 43.28 Quite Low
Inflammatory stimuli 8 12.92 Low Low
chemokine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 55 97.96 Very High Very High Very High
Death 18 93.68 High High
Apoptosis 4 93.04 High High
Injury 13 90.72 High High
Disease 95 89.96 High High
INFLAMMATION 104 86.24 High High
Stress 13 50.00 Quite Low
Contusions 5 47.48 Quite Low
Adhesions 3 25.68 Quite Low
Neutrophil Disorders 3 6.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gp91phox gene deletion reduces superoxide radical (O2-) production after TBI
Transcription (deletion) of Gp91phox associated with brain injury
1) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 0.76 Pain Relevance 0
COX-2-/- mice showed a higher increase in the expression of p67phox and gp91phox mRNA than COX-2+/+ mice (Fig. 5B and 5C).
Transcription (expression) of gp91phox
2) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.14 Pain Relevance 0.10
Similarly, mRNA levels of NADPH oxidase cytosolic subunit p67phox and membrane subunit gp91phox were significantly elevated at 24 h after LPS injection in both genotypes compared with vehicle-injected controls (Fig. 5B and 5C).
Transcription (levels) of gp91phox
3) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.09 Pain Relevance 0.04
-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?
Transcription (transcripts) of gp91phox in monocytes
4) Confidence 0.36 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03
We found that after 24 weeks, the intensity of gp91PHOX staining microglia was modest and similar in AAV2-SYN injected wild-type mice as well as Fc?
Transcription (microglia) of gp91PHOX in microglia
5) Confidence 0.13 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.08 Pain Relevance 0.10

General Comments

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