INT199090

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.14
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
plasma 5
monocytes 1
microglial cells 1
Ncf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 310 97.72 Very High Very High Very High
narcan 14 92.40 High High
midbrain 28 87.64 High High
opioid receptor 14 86.16 High High
Enkephalin 7 85.52 High High
Inflammatory response 19 75.32 Quite High
cytokine 25 74.52 Quite High
Inflammatory mediators 50 73.28 Quite High
GABAergic 9 50.00 Quite Low
rheumatoid arthritis 14 42.24 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 386 97.72 Very High Very High Very High
Parkinson's Disease 152 96.40 Very High Very High Very High
Disease 231 96.28 Very High Very High Very High
Drug Induced Neurotoxicity 187 95.16 Very High Very High Very High
Apoptosis 6 90.44 High High
Hypertrophy 1 90.00 High High
Pathologic Processes 1 85.40 High High
Death 73 84.84 Quite High
Necrosis 24 82.04 Quite High
Cancer 29 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presently the molecular mechanisms by which SN leads to the inhibition of p47phox translocation are under investigation.
Localization (translocation) of p47phox
1) Confidence 0.41 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.41 Pain Relevance 0.12
The mechanism underlying SN-mediated inhibition of PHOX activity occurs at least in part through the inhibition of the translocation of PHOX cytosolic component p47phox to the plasma membrane, a key event required for extracellular ROS production [31].
Localization (translocation) of p47phox in plasma
2) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.52 Pain Relevance 0.19
As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.
Localization (translocation) of p47phox in plasma
3) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.17
However, the addition of 10-14 M SN significantly prevented this LPS-induced p47phox translocation (Fig. 5, panel V and VI).
Localization (translocation) of p47phox
4) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0 Pain Relevance 0
Therefore, one mechanism by which SN inhibits superoxide production in microglial cells is through inhibition of p47phox translocation to the cell membrane following LPS stimulation.


Localization (translocation) of p47phox in microglial cells
5) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.30 Pain Relevance 0.11
In summary, this study is the first report indicating that SN is a potent anti-inflammatory and neuroprotective agent that acts through inhibition of microglial PHOX-generated superoxide by inhibiting the translocation of p47phox to the plasma membrane.
Localization (translocation) of p47phox in plasma associated with inflammation
6) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.92 Pain Relevance 0.20
Western blot analysis from this study revealed that FLZ inhibited LPS-induced p47phox translocation from cytosol to membrane.
Localization (translocation) of p47phox
7) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.25 Pain Relevance 0
Since apocynin and AEBSF block translocation and binding of p47phox to the Nox-p22phox complex, Nox4 is insensitive to these inhibitors, as previously reported[30]–[32].
Localization (translocation) of p47phox
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
Thus, this result further proves that FLZ-mediated inhibition of superoxide production by LPS is mediated through suppression of p47phox membrane translocation; that is, activation of PHOX.


Localization (translocation) of p47phox
9) Confidence 0.33 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.45 Pain Relevance 0
We found that the translocation of the p47phox subunit from the cytosol to the plasma membrane following LPS stimulation was inhibited by SN.
Localization (translocation) of p47phox in plasma
10) Confidence 0.32 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.29 Pain Relevance 0.19
A critical role for PHOX in FLZ-elicited neuroprotection was further supported by the findings that 1) FLZ's protective effect was reduced in cultures from PHOX-/- mice, and 2) FLZ inhibited LPS-induced translocation of the cytosolic subunit of p47PHOX to the membrane and thus inhibited the activation of PHOX.
Localization (translocation) of p47PHOX
11) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2413210 Disease Relevance 0.79 Pain Relevance 0.11
It has been reported that activation of PHOX holoenzyme is required to initiate the translocation of its cytosolic components p47phox into the plasma membrane [23].
Localization (translocation) of p47phox in plasma
12) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.06 Pain Relevance 0
-treated cultured monocytes and primary microglia [28], there is a translocation of both the p47phox and p67phox subunits from the cytosol to the membrane.
Localization (translocation) of p47phox in monocytes
13) Confidence 0.20 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.10 Pain Relevance 0.04
Apocynin is known to inhibit p47phox and p67phox translocation and superoxide formation through blockade of sulfhydryl groups thus interrupting the NADPH oxidase enzyme assembly [30].
Localization (translocation) of p47phox
14) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.70 Pain Relevance 0.04

General Comments

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