INT199092
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex. | |||||||||||||||
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Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29]. | |||||||||||||||
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Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29]. | |||||||||||||||
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Cytosolic p47phox and p67phox are often found as a complex and both require phosphorylation prior to their translocation to the membrane [34,36]. | |||||||||||||||
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General Comments
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