INT199092

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.43
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
plasma 1
Ncf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 82.08 Quite High
Enkephalin 1 76.44 Quite High
Inflammatory response 7 66.24 Quite High
Inflammation 53 60.04 Quite High
Inflammatory stimuli 2 53.12 Quite High
GABAergic 18 50.00 Quite Low
Inflammatory mediators 8 22.80 Low Low
Hippocampus 27 5.00 Very Low Very Low Very Low
cytokine 24 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 87 67.52 Quite High
INFLAMMATION 71 65.84 Quite High
Drug Induced Neurotoxicity 27 62.40 Quite High
Cognitive Disorder 76 50.00 Quite Low
Stress 8 50.00 Quite Low
Toxicity 6 33.44 Quite Low
Aging 47 29.04 Quite Low
Death 14 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.
p47phox Binding (translocation) of in plasma
1) Confidence 0.19 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.17
Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29].
p47phox Binding (its) of
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29].
p47phox Binding (assembly) of
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0
Cytosolic p47phox and p67phox are often found as a complex and both require phosphorylation prior to their translocation to the membrane [34,36].
p47phox Binding (complex) of
4) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07

General Comments

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