INT199092

Context Info Confidence 0.19 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.43 Pain Relevance 0.24

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1) plasma membrane (Ncf1) cytoplasm (Ncf1)

Anatomy Link Frequency plasma 1 Ncf1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 1 82.08 Enkephalin 1 76.44 Inflammatory response 7 66.24 Inflammation 53 60.04 Inflammatory stimuli 2 53.12 GABAergic 18 50.00 Inflammatory mediators 8 22.80 Hippocampus 27 5.00 cytokine 24 5.00 imagery 14 5.00

Disease Link Frequency Relevance Heat Disease 87 67.52 INFLAMMATION 71 65.84 Drug Induced Neurotoxicity 27 62.40 Cognitive Disorder 76 50.00 Stress 8 50.00 Toxicity 6 33.44 Aging 47 29.04 Death 14 5.00 Neurodegenerative Disease 8 5.00 Cancer 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.

p47phox Binding (translocation) of in plasma

1) Confidence 0.19 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.17

Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29].

p47phox Binding (its) of

2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0

Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29].

p47phox Binding (assembly) of

3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0

Cytosolic p47phox and p67phox are often found as a complex and both require phosphorylation prior to their translocation to the membrane [34,36].

p47phox Binding (complex) of

4) Confidence 0.10 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07

General Comments

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