INT199094

Context Info Confidence 0.36 First Reported 2006 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.55 Pain Relevance 0.26

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1) plasma membrane (Ncf1) cytoplasm (Ncf1)

Anatomy Link Frequency plasma 2 Ncf1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory stimuli 2 95.32 Enkephalin 1 78.20 Inflammation 41 72.32 Inflammatory response 7 68.00 Inflammatory mediators 8 24.56 cytokine 6 5.00 cINOD 6 5.00 midbrain 4 5.00 rheumatoid arthritis 2 5.00 opioid receptor 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 59 95.00 Disease 75 64.64 Drug Induced Neurotoxicity 27 62.68 Stress 6 50.00 Toxicity 6 30.56 Amyloid Plaque 7 12.84 Death 14 5.00 Neurodegenerative Disease 8 5.00 Cognitive Disorder 6 5.00 Alzheimer's Dementia 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.

Positive_regulation (followed) of Phosphorylation (phorsphorylation) of p47phox in plasma

1) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.18

These cytoplasmic signaling events stimulate the phosphorylation of p47phox and p67phox and the GDP/GTP exchange on Rac.

Positive_regulation (stimulate) of Phosphorylation (phosphorylation) of p47phox

2) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

This test has worked.