INT199094

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
plasma 2
Ncf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 95.32 Very High Very High Very High
Enkephalin 1 78.20 Quite High
Inflammation 41 72.32 Quite High
Inflammatory response 7 68.00 Quite High
Inflammatory mediators 8 24.56 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 59 95.00 High High
Disease 75 64.64 Quite High
Drug Induced Neurotoxicity 27 62.68 Quite High
Stress 6 50.00 Quite Low
Toxicity 6 30.56 Quite Low
Amyloid Plaque 7 12.84 Low Low
Death 14 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex.
Positive_regulation (followed) of Phosphorylation (phorsphorylation) of p47phox in plasma
1) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.38 Pain Relevance 0.18
These cytoplasmic signaling events stimulate the phosphorylation of p47phox and p67phox and the GDP/GTP exchange on Rac.
Positive_regulation (stimulate) of Phosphorylation (phosphorylation) of p47phox
2) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

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