INT199095

Context Info Confidence 0.42 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.60 Pain Relevance 0

intracellular (Vav1)

Anatomy Link Frequency B cells 1 Vav1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 1 41.76 cytokine 27 39.12 Inflammation 10 5.00 cINOD 6 5.00 Inflammatory response 5 5.00 anesthesia 3 5.00 chemokine 3 5.00 Inflammatory stimuli 2 5.00 Central nervous system 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 3 85.68 Targeted Disruption 3 74.64 Epstein-barr Virus 54 74.44 Neutrophil Disorders 3 63.52 Infection 103 61.56 Disease 59 60.88 Stress 3 50.00 Sprains And Strains 2 49.40 Lymphatic System Cancer 28 46.24 INFLAMMATION 19 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Madureira et al. [31] and Rodrigues et al. [23] demonstrated that three PXXP motifs located in the C-terminal half of M2 play a role in binding Vav1 and Vav2, and that M2 induces phosphorylation of Vav leading to downstream Rac1 stimulation.

Phosphorylation (phosphorylation) of Vav

1) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.15 Pain Relevance 0

Notably, M2 has been shown to target phosphorylation of the guanosine nucleotide exchange factors Vav1 and Vav2, and more recently has been shown form a trimolecular complex with Vav1 and the Src family tyrosine kinase Fyn [24] - although the functional consequences of these interactions remain unclear.

Phosphorylation (phosphorylation) of Vav1

2) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0 Pain Relevance 0

M2 co-immunoprecipitates with Vav1 in S11 B cells, a MHV68 latently infected cell line, and M2 and Vav1 overexpression in A20 B cells leads to Vav1 phosphorylation, trimerization with Fyn, and downstream activation of Rac1 [27].

Phosphorylation (phosphorylation) of Vav1 in B cells

3) Confidence 0.38 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.20 Pain Relevance 0

The tyrosine phosphorylation of Vav requires fibril engagement of the A?

Phosphorylation (phosphorylation) of Vav

4) Confidence 0.30 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.25 Pain Relevance 0

General Comments

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