INT199095

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Vav1)
Anatomy Link Frequency
B cells 1
Vav1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 41.76 Quite Low
cytokine 27 39.12 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 85.68 High High
Targeted Disruption 3 74.64 Quite High
Epstein-barr Virus 54 74.44 Quite High
Neutrophil Disorders 3 63.52 Quite High
Infection 103 61.56 Quite High
Disease 59 60.88 Quite High
Stress 3 50.00 Quite Low
Sprains And Strains 2 49.40 Quite Low
Lymphatic System Cancer 28 46.24 Quite Low
INFLAMMATION 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Madureira et al. [31] and Rodrigues et al. [23] demonstrated that three PXXP motifs located in the C-terminal half of M2 play a role in binding Vav1 and Vav2, and that M2 induces phosphorylation of Vav leading to downstream Rac1 stimulation.
Phosphorylation (phosphorylation) of Vav
1) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.15 Pain Relevance 0
Notably, M2 has been shown to target phosphorylation of the guanosine nucleotide exchange factors Vav1 and Vav2, and more recently has been shown form a trimolecular complex with Vav1 and the Src family tyrosine kinase Fyn [24] - although the functional consequences of these interactions remain unclear.
Phosphorylation (phosphorylation) of Vav1
2) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0 Pain Relevance 0
M2 co-immunoprecipitates with Vav1 in S11 B cells, a MHV68 latently infected cell line, and M2 and Vav1 overexpression in A20 B cells leads to Vav1 phosphorylation, trimerization with Fyn, and downstream activation of Rac1 [27].
Phosphorylation (phosphorylation) of Vav1 in B cells
3) Confidence 0.38 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.20 Pain Relevance 0
The tyrosine phosphorylation of Vav requires fibril engagement of the A?
Phosphorylation (phosphorylation) of Vav
4) Confidence 0.30 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.25 Pain Relevance 0

General Comments

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