INT199096
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
As the activation of a functional PHOX enzyme requires the phorsphorylation of p47phox followed by the translocation of the p47phox, p67phox, and p40phox complex to the plasma membrane, our results suggest that SN works on one of the earliest stages of PHOX activation to inhibit the assembly of the PHOX enzyme complex. | |||||||||||||||
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It has been demonstrated that HS through HMGB1 activates the TLR4-MyD88-IRAK4 signaling pathway and further activates p38 MAPK and Akt pathways to initiate phosphorylation of p47phox and subsequent activation of NADPH oxidase (Figure 3) [2]. | |||||||||||||||
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Analysis of p47phox and p67phox phosphorylation has been investigated with the use of specific protein kinase inhibitors revealing that protein kinase C (PKC) [37-39], p21-activated kinase-1 (PAK1) [40], mitogen-activated protein kinase (MAPK) [41], Akt [42], and phosphatidylinositol-3 kinase (PI3K) [43] phophorylate p47phox or p67phox. | |||||||||||||||
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These cells also exhibit defects in the phosphorylation and translocation of p47phox [105] and p67phox [106] to the membrane. | |||||||||||||||
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The diversity of kinases implicated in the phosphorylation of p47phox and p67phox suggests that the intracellular signaling pathways responsible for this phosphorylation event are complex and may be cell type and stimulus specific. | |||||||||||||||
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These cytoplasmic signaling events stimulate the phosphorylation of p47phox and p67phox and the GDP/GTP exchange on Rac. | |||||||||||||||
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Analysis of p47phox and p67phox phosphorylation has been investigated with the use of specific protein kinase inhibitors revealing that protein kinase C (PKC) [37-39], p21-activated kinase-1 (PAK1) [40], mitogen-activated protein kinase (MAPK) [41], Akt [42], and phosphatidylinositol-3 kinase (PI3K) [43] phophorylate p47phox or p67phox. | |||||||||||||||
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Upon stimulation, the cytosolic component p47phox is phosphorylated and the entire cytosolic complex migrates to the membrane where it associates with cytochrome b558 to assemble the active oxidase [58]. | |||||||||||||||
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Cytosolic p47phox and p67phox are often found as a complex and both require phosphorylation prior to their translocation to the membrane [34,36]. | |||||||||||||||
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General Comments
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