INT199098

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb)
Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)
Anatomy Link Frequency
monocytes 2
brain 2
Cybb (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 95.00 High High
GABAergic 18 89.92 High High
ketamine 8 73.44 Quite High
cytokine 23 69.76 Quite High
Hippocampus 27 60.56 Quite High
Inflammation 22 24.20 Low Low
Inflammatory stimuli 2 14.48 Low Low
interneuron 10 5.00 Very Low Very Low Very Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 70 91.52 High High
Aging 47 87.36 High High
Cognitive Disorder 76 57.76 Quite High
Stress 5 50.00 Quite Low
Schizophrenia 4 30.00 Quite Low
Cancer 5 27.60 Quite Low
INFLAMMATION 31 24.20 Low Low
Neutrophil Disorders 3 6.88 Low Low
Death 8 5.00 Very Low Very Low Very Low
Amyloid Plaque 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specificity of SN50 has previously been confirmed in these same cultures by EMSA using an inactive peptide, SN50M.[37] These results suggest that Nox2 activation/induction is dependent on NF?
Positive_regulation (dependent) of Positive_regulation (induction) of Nox2
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.15 Pain Relevance 0.12
To confirm that elevation of brain IL-6 and induction of Nox2 described above led to increased Nox2-dependent superoxide production in vivo, we assessed superoxide levels using confocal imaging of dihydroethidium (DHE) oxidation to its fluorescent product (ox-DHE) in fixed brain slices prepared from DHE-injected young mice, and from DHE-injected old mice that had been treated for 7 days prior to DHE with either no drug, or with the NADPH oxidase inhibitor, apocynin, in their drinking water.
Positive_regulation (elevation) of Positive_regulation (induction) of Nox2 in brain associated with imagery
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0.11
-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?
Positive_regulation (results) of Positive_regulation (increase) of gp91phox in monocytes
3) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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