INT199098

Context Info Confidence 0.47 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.24 Pain Relevance 0.26

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)

Anatomy Link Frequency monocytes 2 brain 2 Cybb (Mus musculus)

Pain Link Frequency Relevance Heat imagery 12 95.00 GABAergic 18 89.92 ketamine 8 73.44 cytokine 23 69.76 Hippocampus 27 60.56 Inflammation 22 24.20 Inflammatory stimuli 2 14.48 interneuron 10 5.00 long-term potentiation 6 5.00 anesthesia 6 5.00

Disease Link Frequency Relevance Heat Disease 70 91.52 Aging 47 87.36 Cognitive Disorder 76 57.76 Stress 5 50.00 Schizophrenia 4 30.00 Cancer 5 27.60 INFLAMMATION 31 24.20 Neutrophil Disorders 3 6.88 Death 8 5.00 Amyloid Plaque 7 5.00

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Negation

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The specificity of SN50 has previously been confirmed in these same cultures by EMSA using an inactive peptide, SN50M.[37] These results suggest that Nox2 activation/induction is dependent on NF?

Positive_regulation (dependent) of Positive_regulation (induction) of Nox2

1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.15 Pain Relevance 0.12

To confirm that elevation of brain IL-6 and induction of Nox2 described above led to increased Nox2-dependent superoxide production in vivo, we assessed superoxide levels using confocal imaging of dihydroethidium (DHE) oxidation to its fluorescent product (ox-DHE) in fixed brain slices prepared from DHE-injected young mice, and from DHE-injected old mice that had been treated for 7 days prior to DHE with either no drug, or with the NADPH oxidase inhibitor, apocynin, in their drinking water.

Positive_regulation (elevation) of Positive_regulation (induction) of Nox2 in brain associated with imagery

2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0.11

-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?

Positive_regulation (results) of Positive_regulation (increase) of gp91phox in monocytes

3) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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