INT1991

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Context Info
Confidence 0.60
First Reported 1979
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 6.97
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sciatic nerve 1
nerve 1
peripheral nerve 1
Schwann cells 1
T cell 1
Ean5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 62 100.00 Very High Very High Very High
Sciatic nerve 7 100.00 Very High Very High Very High
Peripheral nervous system 5 87.28 High High
Demyelination 4 78.00 Quite High
Inflammation 3 74.04 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 62 100.00 Very High Very High Very High
Immunization 10 100.00 Very High Very High Very High
Sprains And Strains 4 99.92 Very High Very High Very High
Syndrome 2 98.16 Very High Very High Very High
Injury 1 96.00 Very High Very High Very High
Multiple Sclerosis 3 95.84 Very High Very High Very High
Paraplegia 1 89.20 High High
Disease 7 84.00 Quite High
Experimental Autoimmune Encephalomyelitis 1 79.52 Quite High
Demyelinating Disease 5 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical and electrophysiological recovery from adoptively transferred EAN was nearly complete and its time course was inversely correlated to the initial severity of EAN.
Gene_expression (transferred) of EAN associated with neuritis
1) Confidence 0.60 Published 1986 Journal Ann. Neurol. Section Abstract Doc Link 2418761 Disease Relevance 0.62 Pain Relevance 0.53
We evaluated the effect of Cl2MDP-liposomes on the course of actively induced and adoptively transferred experimental autoimmune neuritis (EAN), both animal models of the human Guillain-Barré syndrome.
Gene_expression (transferred) of EAN associated with syndrome, experimental autoimmune neuritis and neuritis
2) Confidence 0.50 Published 1993 Journal J. Neurol. Sci. Section Abstract Doc Link 8277335 Disease Relevance 0.72 Pain Relevance 0.56
The present data fail to support an enhancing role for gangliosides in the expression of EAN and, by extrapolation, in the Guillain-Barré syndrome, for which EAN serves as the laboratory model, and in which suggestions have been made that antibodies to GA may have pathogenetic significance.
Gene_expression (expression) of EAN associated with syndrome and neuritis
3) Confidence 0.37 Published 1991 Journal Ann. Neurol. Section Abstract Doc Link 1722387 Disease Relevance 0.68 Pain Relevance 0.64
There did not appear to be a correlation between the amount of P2 protein contained in the different myelin species and the severity of the EAN symptoms and lesions produced.
Gene_expression (produced) of EAN associated with neuritis
4) Confidence 0.36 Published 1979 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 312920 Disease Relevance 0.94 Pain Relevance 0.62
At least one neuritogenic epitope for each strain was present in the cyanogen bromide-derived peptide CB2 (residues 21-113), as shown by the ability of CB2-specific T cell lines derived from each strain to transfer EAN to the appropriate host strain.
Gene_expression (transfer) of EAN in T cell associated with sprains and strains and neuritis
5) Confidence 0.21 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2431045 Disease Relevance 1.23 Pain Relevance 0.61
This study examined the expression of constitutive endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) in the sciatic nerve of Lewis rats with experimental autoimmune neuritis (EAN).
Spec (examined) Gene_expression (expression) of EAN in sciatic nerve associated with experimental autoimmune neuritis, sciatic nerve and neuritis
6) Confidence 0.20 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12020959 Disease Relevance 0.67 Pain Relevance 0.79
This study reports the cellular localization of gamma-interferon (gamma-IFN) in nerve roots during the course of experimental autoimmune neuritis induced either by active immunization (EAN) or adoptive transfer of P2-specific T-cells (AT-EAN).
Gene_expression (transfer) of AT-EAN in nerve associated with experimental autoimmune neuritis, immunization and neuritis
7) Confidence 0.19 Published 1992 Journal Brain Section Abstract Doc Link 1486454 Disease Relevance 0.90 Pain Relevance 0.21
OBJECTIVE: To investigate the expression of the integrin alpha6beta4 in experimental allergic neuritis (EAN) and the relationship of the integrin alpha6beta4 with functional states of Schwann cells (Sc) as well as the injury and repair of the myelin during EAN.
Spec (investigate) Gene_expression (expression) of EAN in Schwann cells associated with experimental autoimmune neuritis, injury and neuritis
8) Confidence 0.17 Published 2003 Journal Zhonghua Bing Li Xue Za Zhi Section Abstract Doc Link 12882692 Disease Relevance 0.47 Pain Relevance 0.37
The expression of co-stimulatory molecules CD40 and CD40L was examined over the course of experimental autoimmune neuritis (EAN) induced in Lewis rats by immunization with bovine peripheral nerve myelin.
Gene_expression (expression) of EAN in peripheral nerve associated with experimental autoimmune neuritis, immunization and neuritis
9) Confidence 0.14 Published 2007 Journal Neurobiol. Dis. Section Abstract Doc Link 17188497 Disease Relevance 0.75 Pain Relevance 0.52

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