INT199100

Context Info Confidence 0.19 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.83 Pain Relevance 0.03

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1) plasma membrane (Ncf1) cytoplasm (Ncf1)

Anatomy Link Frequency monocytes 2 Ncf1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 6 66.24 Inflammatory stimuli 2 10.96 Inflammation 12 5.00 cINOD 6 5.00 Inflammatory response 5 5.00 chemokine 2 5.00 Central nervous system 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Aging 125 96.24 Obesity 169 95.84 Disease 59 88.00 Stress 20 50.00 Congenital Anomalies 1 21.04 INFLAMMATION 21 10.60 Neutrophil Disorders 3 10.56 Death 12 5.00 Amyloid Plaque 7 5.00 Alzheimer's Dementia 6 5.00

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Protein

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Event

Anatomy

Negation

Speculation

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Disease term

-stimulation also results in a relative increase in mRNA transcripts for both p47phox and gp91phox and an increase in p47phox protein expression in monocytes primed with INF?

Positive_regulation (increase) of Gene_expression (expression) of p47phox in monocytes

1) Confidence 0.19 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.09 Pain Relevance 0.03

production and upregulated expression of p47phox NADPH oxidase without an additive effect of the two.

Positive_regulation (upregulated) of Gene_expression (expression) of p47phox

2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.75 Pain Relevance 0

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