INT199127

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.55
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FBN2) proteinaceous extracellular matrix (FBN2)
Anatomy Link Frequency
colon 1
connective tissue 1
FBN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 9 73.00 Quite High
chemokine 6 28.32 Quite Low
cytokine 12 27.88 Quite Low
Inflammation 19 5.00 Very Low Very Low Very Low
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 30 97.80 Very High Very High Very High
Syndrome 6 94.00 High High
Hypertension 9 83.76 Quite High
Stress 3 81.56 Quite High
Marfan Syndrome 6 77.04 Quite High
INFLAMMATION 28 72.64 Quite High
Targeted Disruption 41 71.80 Quite High
Atherosclerosis 27 69.00 Quite High
Stress Incontinence 12 68.84 Quite High
Congenital Anomalies 15 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A primer pair (ConForw: ctg gac tct gac atg tgc aca tac; ConRev: cta cat gca gga tga cca gca tag) complementary for Connexin 31 was used as a control (data not shown).
Gene_expression (tct) of cca
1) Confidence 0.65 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.20 Pain Relevance 0
Fibrillin 1 is expressed exclusively in vascular SMCs while fibrillin 2 is found also in colon SMCs (Figure 2B).
Gene_expression (found) of fibrillin 2 in colon
2) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.13 Pain Relevance 0.06
The differential expression of fibrillin 1 and fibrillin 2 in SMCs may be related to the anatomic specificity of diseases that result from defects of these proteins.
Gene_expression (expression) of fibrillin 2 associated with disease
3) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.03 Pain Relevance 0.07
For example, colonic SMCs expressed fibrillin-2 (Figure 4B), a component of connective tissue microfibrils that is involved in elastic fiber assembly, organization of the ECM (which allows it to influence the physical properties of connective tissue), and regulation of growth factor signaling (which allows it to also direct a broad spectrum of cellular activities) [51].
Gene_expression (expressed) of fibrillin-2 in connective tissue
4) Confidence 0.23 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.19 Pain Relevance 0

General Comments

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