INT199146

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 3.57
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
melanocytes 1
Pheo (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 8 94.96 High High
Dopamine 2 92.24 High High
antagonist 6 92.08 High High
melanocortin 1 receptor 66 91.80 High High
headache 2 86.88 High High
adenocard 6 86.72 High High
imagery 8 65.24 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Glial derived neurotrophic factor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pheochromocytoma 48 100.00 Very High Very High Very High
Thyroid Neoplasm 124 99.80 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2b 42 99.32 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 122 98.92 Very High Very High Very High
Anxiety 2 87.96 High High
Heart Rate Under Development 2 87.44 High High
Headache 2 86.88 High High
Hypertension 2 86.12 High High
Disease 10 80.44 Quite High
Syndrome 18 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is the biochemical interaction between these two proteins that controls the switch between dark eumelanin and light pheomelanin production in melanocytes.
Gene_expression (production) of pheomelanin in melanocytes
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.45
The production of eumelanin (brown or black pigment) and pheomelanin (yellow or red pigment) is controlled to a large part by the interaction of the two proteins [42], [44], [45].
Gene_expression (production) of pheomelanin
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0.08 Pain Relevance 0.47
Most melanogenesis leads to the production of copolymers (or mixtures) of eumelanin and pheomelanin.
Gene_expression (production) of pheomelanin
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.33
Intervention of cysteine leads to the production of pheomelanin.
Gene_expression (production) of pheomelanin
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0
Significant differences were obtained in pheomelanin contents (F(5, 24)?
Gene_expression (contents) of pheomelanin
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0
0.0129; Figure 4B) and the eumelanin/pheomelanin ratio (F(5, 24)?
Gene_expression (ratio) of pheomelanin
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0
Recently, a microarray expression analysis of PHEO and MTC tissues from patients with MEN2A and MEN2B demonstrated different gene expression profiles, possibly explaining the more aggressive nature of MEN2B [26].


Gene_expression (expression) of PHEO associated with multiple endocrine neoplasia type 2a, thyroid neoplasm, multiple endocrine neoplasia type 2b and pheochromocytoma
7) Confidence 0.08 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 1.27 Pain Relevance 0
If PHEO is detected, adrenalectomy should be performed before thyroidectomy or any other surgical intervention, in order to avoid intraoperative catecholamine crisis.
Gene_expression (detected) of PHEO associated with catecholamine and pheochromocytoma
8) Confidence 0.08 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 2.23 Pain Relevance 0.38

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